Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A-375 | Vemurafenib | Belinostat | 3.160 | 1.000 | uM | 72 | hr | 3 | 1148 | 705 | 0.0338 | 0.0484 | 0.6141 | 0.5323 |
| COLO 858 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 2 | 1148 | 502 | 0.1493 | 0.1445 | 0.4373 | 0.4584 |
| MZ7-mel | Vemurafenib | PF562271 | 1.000 | 0.316 | uM | 72 | hr | 1 | 1150 | 122 | 0.2966 | 0.3680 | 0.1061 | 0.0865 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 3.160 | uM | 72 | hr | 3 | 1150 | 333 | 0.2209 | 0.2489 | 0.2896 | 0.2632 |
| A-375 | Vemurafenib | Saracatinib | 3.160 | 1.000 | uM | 72 | hr | 3 | 1152 | 244 | 0.0475 | 0.0584 | 0.2118 | 0.2015 |
| A-375 | Vemurafenib | Dasatinib | 3.160 | 3.160 | uM | 72 | hr | 3 | 1153 | 176 | 0.0495 | 0.0492 | 0.1526 | 0.1635 |
| MZ7-mel | Vemurafenib | JNK-IN-8 | 1.000 | 0.000 | uM | 72 | hr | 1 | 1154 | 182 | 0.3082 | 0.4353 | 0.1577 | 0.1651 |
| COLO 858 | Vemurafenib | PF562271 | 1.000 | 0.316 | uM | 72 | hr | 1 | 1154 | 797 | 0.0644 | 0.0514 | 0.6906 | 0.7028 |
| COLO 858 | Vemurafenib | Saracatinib | 3.160 | 0.000 | uM | 72 | hr | 1 | 1155 | 902 | 0.0429 | 0.0307 | 0.7810 | 0.8523 |
| MZ7-mel | Vemurafenib | JNK-IN-8 | 1.000 | 0.316 | uM | 72 | hr | 1 | 1156 | 177 | 0.3104 | 0.2894 | 0.1531 | 0.1571 |
| WM-115 | Vemurafenib | Dasatinib | 1.000 | 3.160 | uM | 72 | hr | 1 | 1156 | 371 | 0.1960 | 0.2060 | 0.3209 | 0.3157 |
| MMAC-SF | Vemurafenib | JNK-IN-8 | 0.000 | 0.316 | uM | 72 | hr | 1 | 1158 | 56 | 1.0822 | 1.3028 | 0.0484 | 0.0415 |
| COLO 858 | Vemurafenib | JNK-IN-8 | 1.000 | 1.000 | uM | 72 | hr | 3 | 1163 | 800 | 0.0602 | 0.0651 | 0.6879 | 0.6828 |
| COLO 858 | Vemurafenib | I-BET151 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1163 | 835 | 0.0758 | 0.0871 | 0.7180 | 0.7176 |
| MZ7-mel | Vemurafenib | Dasatinib | 1.000 | 0.316 | uM | 72 | hr | 1 | 1165 | 126 | 0.2089 | 0.2583 | 0.1082 | 0.1001 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 1.000 | uM | 72 | hr | 2 | 1166 | 605 | 0.1400 | 0.1470 | 0.5189 | 0.4830 |
| WM-115 | Vemurafenib | Belinostat | 1.000 | 1.000 | uM | 72 | hr | 3 | 1167 | 247 | 0.2638 | 0.2809 | 0.2117 | 0.2175 |
| COLO 858 | Vemurafenib | Belinostat | 0.316 | 1.000 | uM | 72 | hr | 2 | 1168 | 658 | 0.1170 | 0.1069 | 0.5634 | 0.5774 |
| A-375 | Vemurafenib | Dasatinib | 0.316 | 1.000 | uM | 72 | hr | 2 | 1173 | 45 | 0.0571 | 0.0577 | 0.0384 | 0.0487 |
| COLO 858 | Vemurafenib | Belinostat | 0.316 | 1.000 | uM | 72 | hr | 1 | 1176 | 674 | 0.1152 | 0.1069 | 0.5731 | 0.5774 |
| MZ7-mel | Vemurafenib | Saracatinib | 0.316 | 0.000 | uM | 72 | hr | 1 | 1177 | 92 | 0.3539 | 0.5276 | 0.0782 | 0.0734 |
| COLO 858 | Vemurafenib | Defactinib | 0.100 | 3.160 | uM | 72 | hr | 3 | 1178 | 697 | 0.0571 | 0.0598 | 0.5917 | 0.6178 |
| WM-115 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 3 | 1178 | 671 | 0.1556 | 0.1743 | 0.5696 | 0.5669 |
| COLO 858 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 2 | 1178 | 702 | 0.1100 | 0.1085 | 0.5959 | 0.5981 |
| COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 1.000 | uM | 72 | hr | 1 | 1181 | 405 | 0.2356 | 0.1822 | 0.3429 | 0.4375 |