Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 1 840 724 0.0166 0.0153 0.8619 0.8976
MMAC-SF Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 1 840 273 0.4343 0.3712 0.3250 0.3204
MMAC-SF Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 3 843 145 0.7067 0.5785 0.1720 0.1867
MMAC-SF Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 3 850 32 0.6527 0.8133 0.0376 0.0417
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 3 850 795 0.0065 0.0047 0.9353 0.9535
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 854 49 0.7905 0.7915 0.0574 0.0491
MMAC-SF Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 1 855 222 0.5051 0.5481 0.2596 0.2669
COLO 858 Vemurafenib (+)-JQ1 1.000 0.000
uM
 72
hr
 1 856 414 0.1342 0.2031 0.4836 0.4582
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 3 858 500 0.0646 0.0793 0.5828 0.5384
MMAC-SF Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 3 859 138 0.7300 0.6679 0.1607 0.1517
MMAC-SF Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 2 859 151 0.5423 0.5371 0.1758 0.1786
MMAC-SF Vemurafenib JNK-IN-8 0.316 3.160
uM
 72
hr
 1 860 78 0.7679 0.6000 0.0907 0.1021
MZ7-mel Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 862 123 0.1624 0.2476 0.1427 0.1178
MMAC-SF Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 3 862 273 0.4511 0.3972 0.3167 0.3126
MZ7-mel Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 3 863 158 0.2034 0.1862 0.1831 0.1658
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 864 753 0.0132 0.0137 0.8715 0.8777
MMAC-SF Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 3 865 273 0.5994 0.5184 0.3156 0.2893
MMAC-SF Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 2 867 41 0.6326 0.6038 0.0473 0.0460
MMAC-SF Vemurafenib JNK-IN-8 0.316 0.316
uM
 72
hr
 3 868 106 0.7483 0.6759 0.1221 0.1363
MZ7-mel Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 3 869 203 0.1463 0.2468 0.2336 0.2247
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 3 869 37 0.8424 0.8032 0.0426 0.0480
MMAC-SF Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 2 871 154 0.7041 0.6805 0.1768 0.1572
MZ7-mel Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 873 185 0.1384 0.1382 0.2119 0.2130
MMAC-SF Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 2 873 73 0.6127 0.5614 0.0836 0.0959
MZ7-mel Vemurafenib Dasatinib 1.000 1.000
uM
 72
hr
 3 875 69 0.1621 0.2297 0.0789 0.0870