Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 2 1479 1417 0.0074 0.0082 0.9581 0.9545
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 1556 1484 0.0085 0.0082 0.9537 0.9545
A-375 Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 1 2592 213 0.1140 0.1060 0.0822 0.0803
WM-115 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 3 2349 217 0.5096 0.5180 0.0924 0.0997
COLO 858 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 3 1810 1651 0.0189 0.0193 0.9122 0.9069
COLO 858 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 2 1727 1557 0.0202 0.0193 0.9016 0.9069
A-375 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 3 3044 145 0.1389 0.1394 0.0476 0.0554
COLO 858 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 1712 1553 0.0189 0.0193 0.9071 0.9069
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 864 753 0.0132 0.0137 0.8715 0.8777
WM-115 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 1 2505 277 0.5325 0.5180 0.1106 0.0997
WM-115 Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 1 1903 274 0.3894 0.3746 0.1440 0.1465
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 2 1025 897 0.0152 0.0137 0.8751 0.8777
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 1 933 827 0.0126 0.0137 0.8864 0.8777
WM-115 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 1 2678 293 0.5701 0.5734 0.1094 0.1079
COLO 858 Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 3 1293 1060 0.0277 0.0294 0.8198 0.8047
COLO 858 Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 2 1294 999 0.0350 0.0294 0.7720 0.8047
WM-115 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 2 2706 306 0.5737 0.5734 0.1131 0.1079
COLO 858 Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 1 1205 991 0.0254 0.0294 0.8224 0.8047
COLO 858 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 3 1675 1292 0.0455 0.0451 0.7713 0.7585
A-375 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 2 3261 223 0.1456 0.1394 0.0684 0.0554
COLO 858 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 2 1493 1144 0.0414 0.0451 0.7662 0.7585
COLO 858 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 1 1557 1149 0.0484 0.0451 0.7380 0.7585
A-375 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 1 2938 147 0.1338 0.1394 0.0500 0.0554
WM-115 Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 3 2684 272 0.5765 0.5734 0.1013 0.1079
WM-115 Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 2 1877 261 0.3863 0.3746 0.1391 0.1465