Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 1 3016 167 0.1443 0.1539 0.0554 0.0544
COLO 858 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 2637 462 0.3107 0.3034 0.1752 0.1673
COLO 858 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 2 1208 870 0.0483 0.0508 0.7202 0.7144
COLO 858 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 1 1252 898 0.0506 0.0508 0.7173 0.7144
MMAC-SF Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 2 867 41 0.6326 0.6038 0.0473 0.0460
WM-115 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 3 2626 435 0.5469 0.5260 0.1657 0.1795
A-375 Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 3 2383 59 0.1177 0.1200 0.0248 0.0313
WM-115 Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 1 2234 406 0.4563 0.4479 0.1817 0.1688
WM-115 Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 2 2185 353 0.4573 0.4479 0.1616 0.1688
A-375 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 3 962 146 0.0413 0.0433 0.1518 0.1382
WM-115 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 2034 549 0.3707 0.3578 0.2699 0.2762
MMAC-SF Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 3 1078 44 0.7919 0.7554 0.0408 0.0454
MMAC-SF Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 3 653 30 0.4772 0.6038 0.0459 0.0460
WM-115 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 2538 469 0.5165 0.5321 0.1848 0.1853
A-375 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 5334 374 0.2512 0.2714 0.0701 0.0654
WM-115 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 2659 466 0.5474 0.5321 0.1753 0.1853
WM-115 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 1 2653 520 0.5325 0.5321 0.1960 0.1853
A-375 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 2 1035 135 0.0456 0.0433 0.1304 0.1382
WM-115 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 1 2591 461 0.5317 0.5260 0.1779 0.1795
MMAC-SF Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 915 46 0.6656 0.7554 0.0503 0.0454
WM-115 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 2 2484 484 0.4993 0.5260 0.1948 0.1795
A-375 Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 2 2276 92 0.1106 0.1200 0.0404 0.0313
WM-115 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 2 1955 588 0.3412 0.3578 0.3008 0.2762
A-375 Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 1 4220 165 0.2053 0.1658 0.0391 0.0359
A-375 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 1 982 130 0.0431 0.0433 0.1324 0.1382