Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 2 1951 375 0.2251 0.2433 0.1922 0.1994
A-375 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 914 160 0.0382 0.0434 0.1751 0.1958
COLO 858 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 2 1560 1386 0.0249 0.0314 0.8885 0.8595
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 1 1135 1078 0.0081 0.0064 0.9498 0.9579
COLO 858 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 1681 1503 0.0254 0.0314 0.8941 0.8595
A-375 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 1196 197 0.0506 0.0492 0.1647 0.1635
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 1093 1032 0.0087 0.0084 0.9442 0.9531
A-375 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 2 1221 62 0.0587 0.0545 0.0508 0.0467
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 1 1440 1382 0.0083 0.0084 0.9597 0.9531
A-375 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 1138 197 0.0477 0.0492 0.1731 0.1635
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 1247 1183 0.0091 0.0097 0.9487 0.9430
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 1115 1046 0.0099 0.0097 0.9381 0.9430
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 1231 1160 0.0101 0.0097 0.9423 0.9430
A-375 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 1153 176 0.0495 0.0492 0.1526 0.1635
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 19971 929 0.9642 1.0000 0.0465 0.0504
A-375 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 8666 164 0.4305 0.4180 0.0189 0.0173
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 7914 1171 0.9632 1.0000 0.1480 0.1514
A-375 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 3 1056 45 0.0512 0.0545 0.0426 0.0467
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 8309 1285 1.0034 1.0000 0.1547 0.1514
MMAC-SF Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 451 88 0.2780 0.2918 0.1951 0.1993
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 8526 1292 1.0334 1.0000 0.1515 0.1514
A-375 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 1 1292 66 0.0621 0.0577 0.0511 0.0487
COLO 858 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 2337 557 0.2543 0.2671 0.2383 0.2394
MMAC-SF Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 3 753 46 0.5415 0.7322 0.0611 0.0524
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 1 1253 76 0.9015 1.0853 0.0607 0.0619