Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 2628 159 0.4965 0.3530 0.0605 0.0606
WM-115 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 1013 473 0.1348 0.1470 0.4669 0.4830
COLO 858 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 3 964 847 0.0355 0.0535 0.8786 0.8621
MZ7-mel Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 3 1537 88 0.2914 0.2872 0.0573 0.0593
WM-115 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 3 1227 649 0.1443 0.1543 0.5289 0.4970
A-375 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 3 975 220 0.0411 0.0432 0.2256 0.2026
MZ7-mel Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 3 1416 87 0.2673 0.3781 0.0614 0.0626
WM-115 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 2042 430 0.4024 0.4161 0.2106 0.2078
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 2006 239 0.0847 0.0889 0.1191 0.1262
MZ7-mel Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 3308 163 0.6325 0.5541 0.0493 0.0507
WM-115 Vemurafenib Dasatinib 1.000 3.160
uM
 72
hr
 3 1251 376 0.2184 0.2060 0.3006 0.3157
COLO 858 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 3 1480 1221 0.0786 0.0787 0.8250 0.7868
MZ7-mel Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 3 2847 207 0.5309 0.4729 0.0727 0.0666
WM-115 Vemurafenib Dasatinib 1.000 1.000
uM
 72
hr
 3 1340 471 0.2169 0.2248 0.3515 0.3610
A-375 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 3 2124 82 0.1111 0.1343 0.0386 0.0352
MZ7-mel Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 3 1666 130 0.3089 0.4188 0.0780 0.0678
WM-115 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 3 1388 504 0.2207 0.2193 0.3631 0.3870
A-375 Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 3 1677 72 0.0813 0.0917 0.0429 0.0407
MZ7-mel Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 3 1425 70 0.2725 0.3555 0.0491 0.0539
WM-115 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 3 2673 333 0.5841 0.5745 0.1246 0.1322
COLO 858 Vemurafenib (+)-JQ1 3.160 1.000
uM
 72
hr
 3 1037 892 0.0440 0.0609 0.8602 0.8549
MZ7-mel Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 2625 208 0.4861 0.4216 0.0792 0.0846
WM-115 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 3 1604 415 0.2968 0.2889 0.2587 0.3083
A-375 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 3 3852 93 0.2045 0.1991 0.0241 0.0233
MZ7-mel Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 3 1879 128 0.3521 0.3242 0.0681 0.0687