Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 3 794 69 0.4467 0.5287 0.0869 0.0889
WM-115 Vemurafenib Saracatinib 1.000 0.316
uM
 72
hr
 3 2364 364 0.5201 0.5099 0.1540 0.1408
A-375 Vemurafenib I-BET 0.100 0.000
uM
 72
hr
 3 7332 213 0.5221 0.5189 0.0291 0.0308
MMAC-SF Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 633 84 0.3383 0.4387 0.1327 0.1238
WM-115 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 3 2523 353 0.5643 0.5494 0.1399 0.1416
A-375 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 3 1744 239 0.0788 0.0842 0.1370 0.1524
MMAC-SF Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 3 1046 176 0.5360 0.5003 0.1683 0.1840
WM-115 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 3 2084 267 0.4725 0.4743 0.1281 0.1338
A-375 Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 3 1557 332 0.0587 0.0613 0.2132 0.2108
MMAC-SF Vemurafenib Defactinib 0.316 0.316
uM
 72
hr
 3 965 257 0.4362 0.4219 0.2663 0.2479
WM-115 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 3 1953 173 0.4629 0.4954 0.0886 0.0888
A-375 Vemurafenib I-BET 0.100 1.000
uM
 72
hr
 3 3934 188 0.2747 0.3080 0.0478 0.0484
MMAC-SF Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 3 612 155 0.2816 0.3619 0.2533 0.2613
WM-115 Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 3 2867 273 0.6745 0.6528 0.0952 0.0956
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 3 2950 229 0.1424 0.1538 0.0776 0.0753
MMAC-SF Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 3 562 189 0.2298 0.2686 0.3363 0.3262
WM-115 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 3 2855 245 0.6787 0.7069 0.0858 0.0799
WM-115 Vemurafenib I-BET151 3.160 0.000
uM
 72
hr
 3 1908 303 0.4600 0.4718 0.1588 0.1680
MMAC-SF Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 881 262 0.3814 0.3551 0.2974 0.3208
WM-115 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 3 2278 211 0.5375 0.5553 0.0926 0.0985
A-375 Vemurafenib I-BET 0.316 0.000
uM
 72
hr
 3 3925 119 0.2791 0.2900 0.0303 0.0255
MMAC-SF Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 3 750 271 0.2951 0.2855 0.3613 0.3352
WM-115 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 3 2787 194 0.6743 0.6617 0.0696 0.0684
A-375 Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 3 1115 111 0.0526 0.0571 0.0996 0.0996
MMAC-SF Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 3 625 262 0.2237 0.2820 0.4192 0.3755