Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 1 2653 212 0.6598 0.7324 0.0799 0.0776
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 1 9635 173 0.4953 0.4364 0.0180 0.0207
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 1 11677 368 0.7113 0.6866 0.0315 0.0312
COLO 858 Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 1 1205 991 0.0254 0.0294 0.8224 0.8047
A-375 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 1 5747 125 0.2943 0.3050 0.0218 0.0212
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 16963 834 0.7730 0.8197 0.0492 0.0506
A-375 Vemurafenib Saracatinib 1.000 0.316
uM
 72
hr
 1 2328 167 0.1131 0.1190 0.0717 0.0733
A-375 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 1 4016 78 0.2061 0.2010 0.0194 0.0218
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 5745 285 0.3434 0.2974 0.0496 0.0491
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 1556 1484 0.0085 0.0082 0.9537 0.9545
A-375 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 1 3954 69 0.2034 0.1687 0.0175 0.0176
A-375 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 3389 65 0.1683 0.1709 0.0192 0.0246
A-375 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 1 1638 157 0.0775 0.0717 0.0958 0.0989
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 1 4811 91 0.2471 0.2452 0.0189 0.0214
A-375 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 1 7134 125 0.4409 0.4477 0.0175 0.0178
COLO 858 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 3782 731 0.5059 0.4677 0.1933 0.1974
A-375 Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 1 3302 117 0.1667 0.1598 0.0354 0.0325
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 9567 390 0.4398 0.4342 0.0408 0.0408
COLO 858 Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 1 2325 439 0.3128 0.3086 0.1888 0.1792
A-375 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 1 2096 82 0.1054 0.1035 0.0391 0.0423
A-375 Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 1 5860 137 0.3600 0.3831 0.0234 0.0229
A-375 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 1 2098 334 0.0923 0.0842 0.1592 0.1524
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 1649 67 0.0828 0.0757 0.0406 0.0403
WM-115 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 1 1782 333 0.3917 0.3790 0.1869 0.1994
WM-115 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 1 2021 347 0.4525 0.4481 0.1717 0.1607