Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A-375 | Vemurafenib | Dasatinib | 0.316 | 0.316 | uM | 72 | hr | 1 | 1112 | 52 | 0.0537 | 0.0545 | 0.0468 | 0.0467 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 930 | 435 | 0.1236 | 0.1103 | 0.4677 | 0.5337 |
| A-375 | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 1 | 3021 | 208 | 0.1530 | 0.1526 | 0.0689 | 0.0765 |
| A-375 | Vemurafenib | Defactinib | 3.160 | 1.000 | uM | 72 | hr | 1 | 2292 | 344 | 0.0934 | 0.0857 | 0.1501 | 0.1490 |
| COLO 858 | Vemurafenib | Dasatinib | 1.000 | 3.160 | uM | 72 | hr | 1 | 1198 | 988 | 0.0300 | 0.0300 | 0.8247 | 0.8251 |
| A-375 | Vemurafenib | PF562271 | 3.160 | 0.316 | uM | 72 | hr | 1 | 2104 | 186 | 0.1043 | 0.1039 | 0.0884 | 0.0932 |
| A-375 | Vemurafenib | Dasatinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 1196 | 197 | 0.0506 | 0.0492 | 0.1647 | 0.1635 |
| WM-115 | Vemurafenib | Defactinib | 0.100 | 0.316 | uM | 72 | hr | 1 | 3306 | 263 | 0.7274 | 0.7352 | 0.0796 | 0.0764 |
| A-375 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 1 | 2057 | 251 | 0.0982 | 0.0854 | 0.1220 | 0.1306 |
| A-375 | Vemurafenib | Defactinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 1574 | 486 | 0.0521 | 0.0435 | 0.3088 | 0.3296 |
| COLO 858 | Vemurafenib | Dasatinib | 3.160 | 0.316 | uM | 72 | hr | 1 | 1135 | 1078 | 0.0081 | 0.0064 | 0.9498 | 0.9579 |
| A-375 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 1 | 1078 | 291 | 0.0428 | 0.0316 | 0.2699 | 0.3337 |
| A-375 | Vemurafenib | Dasatinib | 0.000 | 1.000 | uM | 72 | hr | 1 | 3016 | 167 | 0.1443 | 0.1539 | 0.0554 | 0.0544 |
| COLO 858 | Vemurafenib | Defactinib | 0.000 | 0.316 | uM | 72 | hr | 1 | 8772 | 1469 | 0.8671 | 0.8985 | 0.1675 | 0.1651 |
| A-375 | Vemurafenib | Saracatinib | 0.000 | 0.000 | uM | 72 | hr | 1 | 20360 | 1046 | 1.0111 | 1.0000 | 0.0514 | 0.0527 |
| A-375 | Vemurafenib | JNK-IN-8 | 0.000 | 0.000 | uM | 72 | hr | 1 | 17029 | 767 | 1.0229 | 1.0000 | 0.0450 | 0.0476 |
| COLO 858 | Vemurafenib | Dasatinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 1247 | 1183 | 0.0091 | 0.0097 | 0.9487 | 0.9430 |
| A-375 | Vemurafenib | Saracatinib | 0.000 | 0.316 | uM | 72 | hr | 1 | 16059 | 813 | 0.7981 | 0.7489 | 0.0506 | 0.0459 |
| A-375 | Vemurafenib | Defactinib | 0.000 | 0.000 | uM | 72 | hr | 1 | 22233 | 990 | 1.0180 | 1.0000 | 0.0445 | 0.0468 |
| COLO 858 | Vemurafenib | Defactinib | 0.000 | 0.000 | uM | 72 | hr | 1 | 10128 | 1461 | 1.0290 | 1.0000 | 0.1443 | 0.1501 |
| A-375 | Vemurafenib | Saracatinib | 0.000 | 1.000 | uM | 72 | hr | 1 | 9957 | 502 | 0.4950 | 0.4801 | 0.0504 | 0.0412 |
| A-375 | Vemurafenib | JNK-IN-8 | 0.000 | 0.316 | uM | 72 | hr | 1 | 15089 | 638 | 0.9090 | 1.0016 | 0.0423 | 0.0383 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 1439 | 366 | 0.2565 | 0.2457 | 0.2543 | 0.2401 |
| WM-115 | Vemurafenib | JNK-IN-8 | 0.316 | 0.316 | uM | 72 | hr | 1 | 2487 | 271 | 0.5605 | 0.5897 | 0.1090 | 0.1058 |
| WM-115 | Vemurafenib | JNK-IN-8 | 0.316 | 0.000 | uM | 72 | hr | 1 | 2777 | 232 | 0.6437 | 0.6349 | 0.0835 | 0.0855 |