Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 3 3116 226 0.7812 0.7324 0.0725 0.0776
MZ7-mel Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 1 2852 143 0.7815 0.9528 0.0501 0.0436
MZ7-mel Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 3 2580 113 0.7822 0.8880 0.0438 0.0519
MZ7-mel Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 2 2523 106 0.7883 0.7091 0.0420 0.0504
WM-115 Vemurafenib (+)-JQ1 0.316 0.000
uM
 72
hr
 2 2781 210 0.7888 0.7819 0.0755 0.0740
WM-115 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 3266 231 0.7892 0.7584 0.0707 0.0699
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 854 49 0.7905 0.7915 0.0574 0.0491
WM-115 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 2 3246 205 0.7908 0.7665 0.0632 0.0659
MMAC-SF Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 3 1078 44 0.7919 0.7554 0.0408 0.0454
MMAC-SF Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 1 1024 31 0.7923 0.6896 0.0303 0.0319
COLO 858 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 5588 784 0.7966 0.8682 0.1403 0.1425
A-375 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 1 15518 861 0.7973 0.8926 0.0555 0.0523
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 16059 813 0.7981 0.7489 0.0506 0.0459
MMAC-SF Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 1047 45 0.7995 0.7976 0.0430 0.0486
WM-115 Vemurafenib (+)-JQ1 0.316 0.000
uM
 72
hr
 3 2794 188 0.7996 0.7819 0.0673 0.0740
WM-115 Vemurafenib I-BET 0.316 0.000
uM
 72
hr
 3 2983 183 0.8032 0.7817 0.0613 0.0634
WM-115 Vemurafenib I-BET 0.000 1.000
uM
 72
hr
 2 2961 158 0.8041 0.8332 0.0534 0.0539
WM-115 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 3 3316 223 0.8043 0.7665 0.0672 0.0659
MZ7-mel Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 2 2697 158 0.8050 0.7710 0.0586 0.0544
WM-115 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 3619 242 0.8072 0.8216 0.0669 0.0659
MMAC-SF Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 2 1106 50 0.8088 0.7554 0.0452 0.0454
MMAC-SF Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 1 1049 35 0.8090 0.9306 0.0334 0.0304
WM-115 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 3 3472 249 0.8152 0.8594 0.0717 0.0671
MZ7-mel Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 2625 125 0.8154 0.7361 0.0476 0.0573
WM-115 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 3 3649 235 0.8160 0.8216 0.0644 0.0659