Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib (+)-JQ1 0.316 1.000
uM
 72
hr
 2 1110 848 0.0795 0.0899 0.7640 0.7359
A-375 Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 2 1659 68 0.0806 0.0917 0.0410 0.0407
A-375 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 1 2119 435 0.0807 0.0825 0.2053 0.1694
COLO 858 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 2 1300 1033 0.0810 0.0787 0.7946 0.7868
COLO 858 Vemurafenib JNK-IN-8 1.000 0.316
uM
 72
hr
 1 1201 711 0.0813 0.0722 0.5920 0.5757
A-375 Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 3 1677 72 0.0813 0.0917 0.0429 0.0407
COLO 858 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 2 1129 649 0.0813 0.0840 0.5748 0.5773
A-375 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 2 1856 299 0.0815 0.0842 0.1611 0.1524
COLO 858 Vemurafenib I-BET151 1.000 1.000
uM
 72
hr
 1 1426 1073 0.0816 0.0720 0.7525 0.7523
COLO 858 Vemurafenib I-BET 1.000 1.000
uM
 72
hr
 3 1033 766 0.0816 0.0928 0.7415 0.7455
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 1649 67 0.0828 0.0757 0.0406 0.0403
COLO 858 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 3 1140 648 0.0833 0.0840 0.5684 0.5773
COLO 858 Vemurafenib (+)-JQ1 3.160 1.000
uM
 72
hr
 1 1645 1369 0.0838 0.0609 0.8322 0.8549
A-375 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 2 1594 450 0.0839 0.0866 0.2823 0.3091
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 2006 239 0.0847 0.0889 0.1191 0.1262
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 1 1035 564 0.0849 0.0793 0.5449 0.5384
A-375 Vemurafenib Belinostat 0.000 1.000
uM
 72
hr
 2 1660 543 0.0853 0.0904 0.3271 0.3077
A-375 Vemurafenib Belinostat 0.100 1.000
uM
 72
hr
 3 1672 550 0.0857 0.0930 0.3289 0.3181
A-375 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 2 1845 254 0.0865 0.0854 0.1377 0.1306
MZ7-mel Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 3 378 104 0.0869 0.1027 0.2751 0.2808
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 1265 531 0.0871 0.1023 0.4198 0.4297
COLO 858 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 1 1252 737 0.0872 0.0840 0.5887 0.5773
A-375 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 3 1711 107 0.0873 0.0988 0.0625 0.0671
A-375 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 2 1858 649 0.0874 0.0884 0.3493 0.3475
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 2 956 466 0.0884 0.0793 0.4874 0.5384