Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 2 726 696 0.0051 0.0054 0.9587 0.9547
COLO 858 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 3 1178 697 0.0571 0.0598 0.5917 0.6178
COLO 858 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 3 5271 697 0.7585 0.7398 0.1322 0.1305
COLO 858 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 3 3469 698 0.4595 0.4677 0.2012 0.1974
WM-115 Vemurafenib (+)-JQ1 3.160 1.000
uM
 72
hr
 2 1263 699 0.1730 0.1677 0.5534 0.5580
COLO 858 Vemurafenib (+)-JQ1 1.000 0.000
uM
 72
hr
 3 1602 701 0.2735 0.2031 0.4376 0.4582
COLO 858 Vemurafenib JNK-IN-8 1.000 0.316
uM
 72
hr
 3 1101 702 0.0662 0.0722 0.6376 0.5757
COLO 858 Vemurafenib I-BET151 0.316 1.000
uM
 72
hr
 2 1178 702 0.1100 0.1085 0.5959 0.5981
COLO 858 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 2 5229 702 0.7507 0.7398 0.1343 0.1305
COLO 858 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 1 1706 704 0.1431 0.1375 0.4127 0.4603
COLO 858 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 1 4700 704 0.4744 0.5301 0.1498 0.1528
A-375 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 3 1148 705 0.0338 0.0484 0.6141 0.5323
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 3 1510 705 0.1452 0.1377 0.4669 0.4424
COLO 858 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 3 957 706 0.0576 0.0767 0.7377 0.7291
WM-115 Vemurafenib Dasatinib 0.316 0.316
uM
 72
hr
 1 1897 707 0.2971 0.2711 0.3727 0.3806
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 1666 709 0.1136 0.1023 0.4256 0.4297
COLO 858 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 2 1738 710 0.1469 0.1453 0.4085 0.3955
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 3 1514 710 0.0955 0.1083 0.4690 0.4526
COLO 858 Vemurafenib JNK-IN-8 1.000 0.316
uM
 72
hr
 1 1201 711 0.0813 0.0722 0.5920 0.5757
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 1609 714 0.1063 0.1023 0.4438 0.4297
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 3 759 718 0.0069 0.0093 0.9460 0.9244
COLO 858 Vemurafenib (+)-JQ1 3.160 0.000
uM
 72
hr
 1 972 720 0.0765 0.0787 0.7407 0.7868
COLO 858 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 2 759 722 0.0061 0.0089 0.9513 0.9423
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 1 840 724 0.0166 0.0153 0.8619 0.8976
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 3 752 724 0.0047 0.0054 0.9628 0.9547