Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 3 910 34 0.5397 0.6001 0.0374 0.0364
MMAC-SF Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 3 1212 34 0.9399 0.9306 0.0281 0.0304
MMAC-SF Vemurafenib PF562271 0.100 1.000
uM
 72
hr
 3 502 35 0.4728 0.5724 0.0697 0.0768
MMAC-SF Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 2 925 35 0.7101 0.6941 0.0378 0.0337
MMAC-SF Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 1 1049 35 0.8090 0.9306 0.0334 0.0304
MMAC-SF Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 2 737 35 0.6894 0.6789 0.0475 0.0471
MMAC-SF Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 3 563 36 0.5175 0.7182 0.0639 0.0494
MMAC-SF Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 3 635 36 0.4779 0.6590 0.0567 0.0562
MMAC-SF Vemurafenib JNK-IN-8 0.100 3.160
uM
 72
hr
 2 757 37 0.7070 0.6959 0.0489 0.0496
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 3 869 37 0.8424 0.8032 0.0426 0.0480
MZ7-mel Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 3 688 38 0.2120 0.3835 0.0552 0.0574
MMAC-SF Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 1 981 39 0.7516 0.7976 0.0398 0.0486
MMAC-SF Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 2 1347 40 1.0428 0.9306 0.0297 0.0304
MMAC-SF Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 1027 40 0.6081 0.4909 0.0389 0.0363
MMAC-SF Vemurafenib PF562271 0.000 1.000
uM
 72
hr
 2 555 40 0.5214 0.6166 0.0721 0.0527
MMAC-SF Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 1 985 40 0.9280 0.7182 0.0406 0.0494
MMAC-SF Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 1 818 40 0.7640 0.6789 0.0489 0.0471
MMAC-SF Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 2 867 41 0.6326 0.6038 0.0473 0.0460
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 894 41 0.8637 0.8032 0.0459 0.0480
MMAC-SF Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 2 984 41 0.7524 0.6896 0.0417 0.0319
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 1 736 41 0.7037 0.8032 0.0557 0.0480
MMAC-SF Vemurafenib PF562271 0.000 1.000
uM
 72
hr
 1 811 41 0.7796 0.6166 0.0506 0.0527
MMAC-SF Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 1 959 43 0.7016 0.6038 0.0448 0.0460
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 1095 43 1.0331 0.7915 0.0393 0.0491
MMAC-SF Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 956 43 0.7285 0.8133 0.0450 0.0417