Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 1 955 894 0.0101 0.0089 0.9361 0.9423
COLO 858 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 3 1041 978 0.0104 0.0089 0.9395 0.9423
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 3 688 647 0.0074 0.0092 0.9404 0.9423
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 1 1199 1142 0.0103 0.0092 0.9525 0.9423
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 2 832 777 0.0099 0.0092 0.9339 0.9423
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 2 736 681 0.0093 0.0093 0.9253 0.9244
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 3 759 718 0.0069 0.0093 0.9460 0.9244
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 1 694 626 0.0115 0.0093 0.9020 0.9244
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 1231 1160 0.0101 0.0097 0.9423 0.9430
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 1247 1183 0.0091 0.0097 0.9487 0.9430
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 1115 1046 0.0099 0.0097 0.9381 0.9430
COLO 858 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 1 1539 1471 0.0115 0.0099 0.9558 0.9514
COLO 858 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 2 1142 1078 0.0108 0.0099 0.9440 0.9514
COLO 858 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 3 963 919 0.0075 0.0099 0.9543 0.9514
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 3 471 427 0.0079 0.0109 0.9066 0.8930
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 2 670 585 0.0153 0.0109 0.8731 0.8930
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 1 526 473 0.0096 0.0109 0.8992 0.8930
COLO 858 Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 3 833 776 0.0103 0.0125 0.9316 0.9029
COLO 858 Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 2 639 572 0.0121 0.0125 0.8951 0.9029
COLO 858 Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 1 712 628 0.0151 0.0125 0.8820 0.9029
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 864 753 0.0132 0.0137 0.8715 0.8777
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 2 1025 897 0.0152 0.0137 0.8751 0.8777
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 1 933 827 0.0126 0.0137 0.8864 0.8777
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 3 1258 1166 0.0131 0.0153 0.9269 0.8976
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 1 840 724 0.0166 0.0153 0.8619 0.8976