Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Belinostat 1.000 1.000
uM
 72
hr
 2 1194 791 0.0925 0.0829 0.6625 0.6809
COLO 858 Vemurafenib Belinostat 1.000 1.000
uM
 72
hr
 1 1214 870 0.0789 0.0829 0.7166 0.6809
COLO 858 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 3 1140 648 0.0833 0.0840 0.5684 0.5773
COLO 858 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 2 1129 649 0.0813 0.0840 0.5748 0.5773
COLO 858 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 1 1252 737 0.0872 0.0840 0.5887 0.5773
A-375 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 1 2098 334 0.0923 0.0842 0.1592 0.1524
A-375 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 2 1856 299 0.0815 0.0842 0.1611 0.1524
A-375 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 3 1744 239 0.0788 0.0842 0.1370 0.1524
A-375 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 3 1515 200 0.0715 0.0854 0.1320 0.1306
A-375 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 2 1845 254 0.0865 0.0854 0.1377 0.1306
A-375 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 1 2057 251 0.0982 0.0854 0.1220 0.1306
A-375 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 3 1822 269 0.0744 0.0857 0.1476 0.1490
A-375 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 2 2192 327 0.0894 0.0857 0.1492 0.1490
A-375 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 1 2292 344 0.0934 0.0857 0.1501 0.1490
A-375 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 3 1534 520 0.0744 0.0866 0.3390 0.3091
A-375 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 2 1594 450 0.0839 0.0866 0.2823 0.3091
A-375 Vemurafenib I-BET 3.160 1.000
uM
 72
hr
 1 1996 611 0.1016 0.0866 0.3061 0.3091
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 3 1163 835 0.0758 0.0871 0.7180 0.7176
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 2 1381 996 0.0890 0.0871 0.7212 0.7176
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 1 1460 1042 0.0966 0.0871 0.7137 0.7176
A-375 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 2 1858 649 0.0874 0.0884 0.3493 0.3475
A-375 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 3 1653 605 0.0758 0.0884 0.3660 0.3475
A-375 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 1 2097 686 0.1020 0.0884 0.3271 0.3475
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 2006 239 0.0847 0.0889 0.1191 0.1262
A-375 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 2198 268 0.0925 0.0889 0.1219 0.1262