Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 3 5769 132 0.2951 0.3050 0.0229 0.0212
A-375 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 1 5747 125 0.2943 0.3050 0.0218 0.0212
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 2 4759 106 0.2436 0.2452 0.0223 0.0214
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 3 4787 110 0.2448 0.2452 0.0230 0.0214
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 1 4811 91 0.2471 0.2452 0.0189 0.0214
A-375 Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 1 3770 78 0.2322 0.2659 0.0207 0.0217
A-375 Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 2 4429 94 0.2727 0.2659 0.0212 0.0217
A-375 Vemurafenib JNK-IN-8 0.316 0.000
uM
 72
hr
 3 4768 111 0.2929 0.2659 0.0233 0.0217
A-375 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 2 4327 93 0.2216 0.2010 0.0215 0.0218
A-375 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 1 4016 78 0.2061 0.2010 0.0194 0.0218
A-375 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 3 3430 84 0.1752 0.2010 0.0245 0.0218
A-375 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 3 4571 110 0.2427 0.2505 0.0241 0.0221
A-375 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 2 5069 97 0.2705 0.2505 0.0191 0.0221
A-375 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 1 4486 104 0.2384 0.2505 0.0232 0.0221
A-375 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 5737 112 0.2848 0.2652 0.0195 0.0225
A-375 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 2 5304 139 0.2615 0.2652 0.0262 0.0225
A-375 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 1 5034 110 0.2493 0.2652 0.0219 0.0225
A-375 Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 3 4607 112 0.2154 0.2489 0.0243 0.0226
A-375 Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 1 5692 119 0.2671 0.2489 0.0209 0.0226
A-375 Vemurafenib Defactinib 0.100 1.000
uM
 72
hr
 2 5639 128 0.2641 0.2489 0.0227 0.0226
A-375 Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 3 6531 140 0.4020 0.3831 0.0214 0.0229
A-375 Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 1 5860 137 0.3600 0.3831 0.0234 0.0229
A-375 Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 2 6306 150 0.3872 0.3831 0.0238 0.0229
A-375 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 2 3786 100 0.2005 0.1991 0.0264 0.0233
A-375 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 3 3852 93 0.2045 0.1991 0.0241 0.0233