Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 1 9635 173 0.4953 0.4364 0.0180 0.0207
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 2 8079 212 0.4118 0.4364 0.0262 0.0207
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 7818 140 0.4019 0.4364 0.0179 0.0207
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 20940 1098 1.0048 1.0000 0.0524 0.0504
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 3 4258 369 0.4617 0.4516 0.0867 0.0851
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 3 3917 151 0.1971 0.1915 0.0385 0.0418
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 3 2950 229 0.1424 0.1538 0.0776 0.0753
COLO 858 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 2717 195 0.4272 0.4664 0.0718 0.0871
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 2 3900 189 0.1943 0.1915 0.0485 0.0418
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 1 3640 140 0.1832 0.1915 0.0385 0.0418
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 8309 1285 1.0034 1.0000 0.1547 0.1514
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 4062 356 0.4400 0.4516 0.0876 0.0851
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 1 4811 91 0.2471 0.2452 0.0189 0.0214
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 2 4759 106 0.2436 0.2452 0.0223 0.0214
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 3 4787 110 0.2448 0.2452 0.0230 0.0214
A-375 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 2 7416 121 0.4589 0.4477 0.0163 0.0178
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 4152 336 0.4531 0.4516 0.0809 0.0851
A-375 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 3 7190 141 0.4434 0.4477 0.0196 0.0178
COLO 858 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 1 1155 902 0.0429 0.0307 0.7810 0.8523
COLO 858 Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 3 3134 506 0.3120 0.2820 0.1615 0.1635
COLO 858 Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 3 2252 1200 0.1249 0.1167 0.5329 0.5321
WM-115 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 1 3738 249 0.8709 0.8638 0.0666 0.0643
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 894 41 0.8637 0.8032 0.0459 0.0480
MMAC-SF Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 1 736 41 0.7037 0.8032 0.0557 0.0480