Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 2 2708 257 0.4420 0.4565 0.0949 0.0817
COLO 858 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 3526 289 0.4624 0.4885 0.0820 0.0896
A-375 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 1 3021 208 0.1530 0.1526 0.0689 0.0765
A-375 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 2 2993 236 0.1500 0.1526 0.0789 0.0765
A-375 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 3 3098 253 0.1548 0.1526 0.0817 0.0765
COLO 858 Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 2 1051 926 0.0207 0.0290 0.8811 0.8526
COLO 858 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 6456 909 1.0004 1.0000 0.1408 0.1418
COLO 858 Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 1 1083 877 0.0342 0.0290 0.8098 0.8526
MMAC-SF Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 1401 69 1.0202 1.0000 0.0493 0.0520
COLO 858 Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 3 1457 1263 0.0322 0.0290 0.8668 0.8526
COLO 858 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 1 6915 1096 1.0494 1.0000 0.1585 0.1418
MMAC-SF Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 2 1049 58 0.7590 0.7202 0.0553 0.0513
MMAC-SF Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 1040 52 0.7567 0.7202 0.0500 0.0513
A-375 Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 3 8666 164 0.4305 0.4180 0.0189 0.0173
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 20360 1046 1.0111 1.0000 0.0514 0.0527
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 20251 1109 1.0021 1.0000 0.0548 0.0527
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 19884 1032 0.9869 1.0000 0.0519 0.0527
A-375 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 2 16317 808 0.9755 1.0000 0.0495 0.0476
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 22233 990 1.0180 1.0000 0.0445 0.0468
A-375 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 3 16730 807 1.0016 1.0000 0.0482 0.0476
MMAC-SF Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 2 743 233 0.3906 0.3972 0.3136 0.3126
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 21096 999 0.9631 1.0000 0.0474 0.0468
COLO 858 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 2637 462 0.3107 0.3034 0.1752 0.1673
MMAC-SF Vemurafenib Defactinib 1.000 0.000
uM
 72
hr
 1 747 248 0.3075 0.3551 0.3320 0.3208
MMAC-SF Vemurafenib Defactinib 0.316 0.000
uM
 72
hr
 3 1046 176 0.5360 0.5003 0.1683 0.1840