Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 2 1886 416 0.3822 0.3772 0.2206 0.2307
WM-115 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 1 1883 435 0.3765 0.3772 0.2310 0.2307
COLO 858 Vemurafenib I-BET151 3.160 0.000
uM
 72
hr
 1 1039 854 0.0428 0.0449 0.8219 0.8382
COLO 858 Vemurafenib I-BET151 3.160 0.000
uM
 72
hr
 2 1213 1019 0.0448 0.0449 0.8401 0.8382
COLO 858 Vemurafenib I-BET151 3.160 0.000
uM
 72
hr
 3 1385 1181 0.0471 0.0449 0.8527 0.8382
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 1 1460 1042 0.0966 0.0871 0.7137 0.7176
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 2 1381 996 0.0890 0.0871 0.7212 0.7176
COLO 858 Vemurafenib I-BET151 3.160 1.000
uM
 72
hr
 3 1163 835 0.0758 0.0871 0.7180 0.7176
A-375 Vemurafenib Belinostat 3.160 0.000
uM
 72
hr
 1 2164 160 0.1530 0.1495 0.0739 0.0897
A-375 Vemurafenib Belinostat 3.160 0.000
uM
 72
hr
 2 2130 167 0.1499 0.1495 0.0784 0.0897
A-375 Vemurafenib Belinostat 3.160 0.000
uM
 72
hr
 3 2158 252 0.1455 0.1495 0.1168 0.0897
A-375 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 1 1468 826 0.0490 0.0484 0.5627 0.5323
A-375 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 2 1407 591 0.0623 0.0484 0.4200 0.5323
A-375 Vemurafenib Belinostat 3.160 1.000
uM
 72
hr
 3 1148 705 0.0338 0.0484 0.6141 0.5323
A-375 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 3 1046 239 0.0422 0.0453 0.2285 0.2134
A-375 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 2 1114 238 0.0459 0.0453 0.2136 0.2134
A-375 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 1 1136 225 0.0477 0.0453 0.1981 0.2134
A-375 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 3 1152 244 0.0475 0.0584 0.2118 0.2015
A-375 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 2 1511 288 0.0640 0.0584 0.1906 0.2015
A-375 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 1 1524 308 0.0637 0.0584 0.2021 0.2015
MZ7-mel Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 1 1318 399 0.1848 0.2350 0.3027 0.3040
MZ7-mel Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 2 1875 585 0.2594 0.2350 0.3120 0.3040
MZ7-mel Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 1844 548 0.2606 0.2350 0.2972 0.3040
MZ7-mel Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 1 776 178 0.1203 0.1382 0.2294 0.2130
MZ7-mel Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 873 185 0.1384 0.1382 0.2119 0.2130