Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib JNK-IN-8 0.100 3.160
uM
 72
hr
 2 757 37 0.7070 0.6959 0.0489 0.0496
COLO 858 Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 2 723 550 0.0312 0.0290 0.7607 0.7843
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 3 4258 369 0.4617 0.4516 0.0867 0.0851
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 2 4062 356 0.4400 0.4516 0.0876 0.0851
COLO 858 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 4152 336 0.4531 0.4516 0.0809 0.0851
WM-115 Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 1 3214 278 0.7426 0.7117 0.0865 0.0820
A-375 Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 2 1659 68 0.0806 0.0917 0.0410 0.0407
MMAC-SF Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 3 563 36 0.5175 0.7182 0.0639 0.0494
A-375 Vemurafenib Saracatinib 0.100 0.000
uM
 72
hr
 3 7818 140 0.4019 0.4364 0.0179 0.0207
MMAC-SF Vemurafenib JNK-IN-8 0.100 3.160
uM
 72
hr
 3 548 26 0.5126 0.6959 0.0474 0.0496
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 3 997 51 0.9290 0.8164 0.0512 0.0519
A-375 Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 1 2327 89 0.1133 0.0917 0.0382 0.0407
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 1 734 32 0.6894 0.8164 0.0436 0.0519
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 2 901 55 0.8308 0.8164 0.0610 0.0519
MMAC-SF Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 1 985 40 0.9280 0.7182 0.0406 0.0494
COLO 858 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 3 1227 369 0.1453 0.1780 0.3007 0.3147
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 1 721 33 0.6756 0.8036 0.0458 0.0497
COLO 858 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 1 1836 631 0.2041 0.1780 0.3437 0.3147
COLO 858 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 2 1555 466 0.1845 0.1780 0.2997 0.3147
MMAC-SF Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 2 913 53 0.8445 0.8036 0.0581 0.0497
COLO 858 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 1 1775 484 0.2187 0.3290 0.2727 0.2076
COLO 858 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 2 1561 404 0.1960 0.3290 0.2588 0.2076
WM-115 Vemurafenib JNK-IN-8 0.100 0.316
uM
 72
hr
 2 3200 257 0.7444 0.7245 0.0803 0.0810
COLO 858 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 3 2269 427 0.3120 0.2723 0.1882 0.1881
COLO 858 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 3 3719 340 0.5724 0.3290 0.0914 0.2076