Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 1 2057 547 0.2157 0.2671 0.2659 0.2394
MMAC-SF Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 1 792 31 0.7705 0.6021 0.0391 0.0426
MMAC-SF Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 2 619 26 0.6004 0.6021 0.0420 0.0426
MMAC-SF Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 1135 66 0.8529 1.0000 0.0581 0.0496
MMAC-SF Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 1504 69 1.1449 1.0000 0.0459 0.0496
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 1846 89 1.4019 1.3011 0.0482 0.0459
MMAC-SF Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 1386 59 1.0588 0.8133 0.0426 0.0417
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 7914 1171 0.9632 1.0000 0.1480 0.1514
MMAC-SF Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 3 850 32 0.6527 0.8133 0.0376 0.0417
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 8309 1285 1.0034 1.0000 0.1547 0.1514
MMAC-SF Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 3 696 30 0.5314 0.8059 0.0431 0.0432
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 8526 1292 1.0334 1.0000 0.1515 0.1514
MZ7-mel Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 5344 345 1.0053 1.0000 0.0646 0.0602
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 19971 929 0.9642 1.0000 0.0465 0.0504
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 20360 1046 1.0111 1.0000 0.0514 0.0527
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 20251 1109 1.0021 1.0000 0.0548 0.0527
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 19884 1032 0.9869 1.0000 0.0519 0.0527
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 16059 813 0.7981 0.7489 0.0506 0.0459
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 14559 660 0.7276 0.7489 0.0453 0.0459
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 14373 599 0.7211 0.7489 0.0417 0.0459
A-375 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 9957 502 0.4950 0.4801 0.0504 0.0412
A-375 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 9020 322 0.4553 0.4801 0.0357 0.0412
A-375 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 3 9724 364 0.4900 0.4801 0.0374 0.0412
MZ7-mel Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 1 2499 153 0.4718 0.3781 0.0612 0.0626
MZ7-mel Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 3 1537 88 0.2914 0.2872 0.0573 0.0593