Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | I-BET151 | 0.100 | 1.000 | uM | 72 | hr | 2 | 2496 | 510 | 0.5692 | 0.5488 | 0.2043 | 0.2039 |
| WM-115 | Vemurafenib | I-BET151 | 0.100 | 1.000 | uM | 72 | hr | 3 | 2218 | 457 | 0.5047 | 0.5488 | 0.2060 | 0.2039 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 1 | 2860 | 182 | 0.7676 | 0.7662 | 0.0636 | 0.0650 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 2 | 2905 | 193 | 0.7773 | 0.7662 | 0.0664 | 0.0650 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 3 | 2813 | 183 | 0.7538 | 0.7662 | 0.0651 | 0.0650 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 1 | 2086 | 743 | 0.3849 | 0.3504 | 0.3562 | 0.3582 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 2 | 1893 | 658 | 0.3540 | 0.3504 | 0.3476 | 0.3582 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 3 | 1732 | 642 | 0.3124 | 0.3504 | 0.3707 | 0.3582 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 1 | 2502 | 258 | 0.6432 | 0.6389 | 0.1031 | 0.1025 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 2 | 2545 | 261 | 0.6546 | 0.6389 | 0.1026 | 0.1025 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 3 | 2404 | 245 | 0.6188 | 0.6389 | 0.1019 | 0.1025 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 1 | 1701 | 727 | 0.2792 | 0.2677 | 0.4274 | 0.4255 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 2 | 1659 | 693 | 0.2769 | 0.2677 | 0.4177 | 0.4255 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 3 | 1516 | 654 | 0.2471 | 0.2677 | 0.4314 | 0.4255 |
| WM-115 | Vemurafenib | I-BET151 | 3.160 | 0.000 | uM | 72 | hr | 1 | 2059 | 333 | 0.4947 | 0.4718 | 0.1617 | 0.1680 |
| WM-115 | Vemurafenib | I-BET151 | 3.160 | 0.000 | uM | 72 | hr | 2 | 1968 | 361 | 0.4606 | 0.4718 | 0.1834 | 0.1680 |
| WM-115 | Vemurafenib | I-BET151 | 3.160 | 0.000 | uM | 72 | hr | 3 | 1908 | 303 | 0.4600 | 0.4718 | 0.1588 | 0.1680 |
| WM-115 | Vemurafenib | I-BET151 | 3.160 | 1.000 | uM | 72 | hr | 1 | 1420 | 573 | 0.2428 | 0.2243 | 0.4035 | 0.4138 |
| WM-115 | Vemurafenib | I-BET151 | 3.160 | 1.000 | uM | 72 | hr | 2 | 1283 | 535 | 0.2144 | 0.2243 | 0.4170 | 0.4138 |
| WM-115 | Vemurafenib | I-BET151 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1300 | 547 | 0.2158 | 0.2243 | 0.4208 | 0.4138 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 3 | 1109 | 396 | 0.1927 | 0.2112 | 0.3571 | 0.3403 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 2 | 1197 | 458 | 0.1998 | 0.2112 | 0.3826 | 0.3403 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 1 | 1241 | 349 | 0.2411 | 0.2112 | 0.2812 | 0.3403 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1221 | 296 | 0.2500 | 0.2709 | 0.2424 | 0.2810 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 2 | 1447 | 427 | 0.2757 | 0.2709 | 0.2951 | 0.2810 |