Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 2 5229 702 0.7507 0.7398 0.1343 0.1305
COLO 858 Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 2 723 550 0.0312 0.0290 0.7607 0.7843
COLO 858 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 1 4894 612 0.7101 0.7398 0.1251 0.1305
COLO 858 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 6666 937 0.9500 0.8682 0.1406 0.1425
COLO 858 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 6063 889 0.8580 0.8682 0.1466 0.1425
COLO 858 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 3 2106 339 0.3187 0.2879 0.1610 0.1549
COLO 858 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 5588 784 0.7966 0.8682 0.1403 0.1425
COLO 858 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 3 6377 898 0.9086 1.0000 0.1408 0.1426
COLO 858 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 2 7642 1063 1.0910 1.0000 0.1391 0.1426
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 1 1035 564 0.0849 0.0793 0.5449 0.5384
COLO 858 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 1 7080 1047 1.0004 1.0000 0.1479 0.1426
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 3 850 795 0.0065 0.0047 0.9353 0.9535
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 2 809 781 0.0033 0.0047 0.9654 0.9535
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 1 921 884 0.0044 0.0047 0.9598 0.9535
COLO 858 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 3 1094 1034 0.0071 0.0077 0.9452 0.9513
COLO 858 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 2 1444 1385 0.0070 0.0077 0.9591 0.9513
COLO 858 Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 1 1509 1433 0.0090 0.0077 0.9496 0.9513
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 3 1488 1416 0.0085 0.0082 0.9516 0.9545
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 2 1479 1417 0.0074 0.0082 0.9581 0.9545
COLO 858 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 1556 1484 0.0085 0.0082 0.9537 0.9545
COLO 858 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 3 1810 1651 0.0189 0.0193 0.9122 0.9069
COLO 858 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 2 1727 1557 0.0202 0.0193 0.9016 0.9069
COLO 858 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 1712 1553 0.0189 0.0193 0.9071 0.9069
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 864 753 0.0132 0.0137 0.8715 0.8777
COLO 858 Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 2 1025 897 0.0152 0.0137 0.8751 0.8777