Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib (+)-JQ1 0.100 1.000
uM
 72
hr
 2 1817 782 0.3175 0.3130 0.4304 0.4335
WM-115 Vemurafenib I-BET151 1.000 1.000
uM
 72
hr
 3 1516 654 0.2471 0.2677 0.4314 0.4255
COLO 858 Vemurafenib Belinostat 1.000 0.000
uM
 72
hr
 3 1975 853 0.2574 0.2144 0.4319 0.4251
MMAC-SF Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 2 414 180 0.1442 0.1471 0.4348 0.4142
A-375 Vemurafenib Belinostat 0.316 1.000
uM
 72
hr
 3 1432 626 0.0615 0.0676 0.4372 0.4031
COLO 858 Vemurafenib I-BET151 1.000 0.000
uM
 72
hr
 2 1148 502 0.1493 0.1445 0.4373 0.4584
COLO 858 Vemurafenib (+)-JQ1 1.000 0.000
uM
 72
hr
 3 1602 701 0.2735 0.2031 0.4376 0.4582
COLO 858 Vemurafenib JNK-IN-8 1.000 0.000
uM
 72
hr
 1 1470 646 0.1366 0.1323 0.4395 0.4743
MMAC-SF Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 664 293 0.2841 0.2946 0.4413 0.4049
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 1609 714 0.1063 0.1023 0.4438 0.4297
WM-115 Vemurafenib JNK-IN-8 1.000 3.160
uM
 72
hr
 2 1864 831 0.2613 0.2705 0.4458 0.4169
A-375 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 3 1434 640 0.0562 0.0702 0.4463 0.4350
A-375 Vemurafenib (+)-JQ1 1.000 1.000
uM
 72
hr
 1 1979 884 0.0774 0.0702 0.4467 0.4350
COLO 858 Vemurafenib (+)-JQ1 1.000 0.000
uM
 72
hr
 2 1215 551 0.2016 0.2031 0.4535 0.4582
COLO 858 Vemurafenib I-BET151 1.000 0.000
uM
 72
hr
 1 1055 482 0.1324 0.1445 0.4569 0.4584
WM-115 Vemurafenib (+)-JQ1 0.100 1.000
uM
 72
hr
 3 1722 787 0.2869 0.3130 0.4570 0.4335
COLO 858 Vemurafenib I-BET 1.000 0.000
uM
 72
hr
 1 916 420 0.1516 0.1880 0.4585 0.4335
MMAC-SF Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 475 218 0.1583 0.1742 0.4589 0.4178
MMAC-SF Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 2 706 324 0.2354 0.2403 0.4589 0.4433
COLO 858 Vemurafenib Saracatinib 0.316 0.316
uM
 72
hr
 3 1431 657 0.1311 0.1170 0.4591 0.4614
COLO 858 Vemurafenib (+)-JQ1 0.000 1.000
uM
 72
hr
 2 904 415 0.1484 0.1822 0.4591 0.4375
MMAC-SF Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 3 196 90 0.1073 0.1255 0.4592 0.4181
COLO 858 Vemurafenib Dasatinib 1.000 0.000
uM
 72
hr
 3 2014 926 0.1554 0.1375 0.4598 0.4603
COLO 858 Vemurafenib Defactinib 0.316 1.000
uM
 72
hr
 1 1692 781 0.1082 0.1083 0.4616 0.4526
COLO 858 Vemurafenib Belinostat 1.000 0.000
uM
 72
hr
 2 1665 769 0.2056 0.2144 0.4619 0.4251