Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 2 1741 82 0.4786 0.4655 0.0471 0.0405
MMAC-SF Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 2 867 41 0.6326 0.6038 0.0473 0.0460
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 21096 999 0.9631 1.0000 0.0474 0.0468
MMAC-SF Vemurafenib JNK-IN-8 0.100 3.160
uM
 72
hr
 3 548 26 0.5126 0.6959 0.0474 0.0496
MMAC-SF Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 2 737 35 0.6894 0.6789 0.0475 0.0471
A-375 Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 3 3044 145 0.1389 0.1394 0.0476 0.0554
MZ7-mel Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 2625 125 0.8154 0.7361 0.0476 0.0573
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 1 19613 936 1.0160 1.0000 0.0477 0.0485
MZ7-mel Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 3 2917 139 0.9061 0.7091 0.0477 0.0504
A-375 Vemurafenib I-BET 0.100 1.000
uM
 72
hr
 3 3934 188 0.2747 0.3080 0.0478 0.0484
A-375 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 3 16730 807 1.0016 1.0000 0.0482 0.0476
MMAC-SF Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 1846 89 1.4019 1.3011 0.0482 0.0459
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 3 22342 1082 1.0188 1.0000 0.0484 0.0468
MMAC-SF Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 1158 56 1.0822 1.3028 0.0484 0.0415
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 2 3900 189 0.1943 0.1915 0.0485 0.0418
MZ7-mel Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 4472 217 1.3491 0.9268 0.0485 0.0478
MZ7-mel Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 1 2740 133 0.8503 0.6154 0.0485 0.0443
MZ7-mel Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 2 1645 80 0.3147 0.3555 0.0486 0.0539
MMAC-SF Vemurafenib Dasatinib 0.100 0.000
uM
 72
hr
 1 885 43 0.6449 0.7202 0.0486 0.0513
A-375 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 3 1827 89 0.0910 0.1035 0.0487 0.0423
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 19375 946 1.0025 1.0000 0.0488 0.0485
MMAC-SF Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 1 818 40 0.7640 0.6789 0.0489 0.0471
MMAC-SF Vemurafenib JNK-IN-8 0.100 3.160
uM
 72
hr
 2 757 37 0.7070 0.6959 0.0489 0.0496
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 18973 930 0.9815 1.0000 0.0490 0.0485
MZ7-mel Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 3 1425 70 0.2725 0.3555 0.0491 0.0539