Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 16059 813 0.7981 0.7489 0.0506 0.0459
A-375 Vemurafenib PF562271 0.000 0.316
uM
 72
hr
 1 15518 861 0.7973 0.8926 0.0555 0.0523
A-375 Vemurafenib I-BET151 0.000 0.000
uM
 72
hr
 2 15439 1571 1.0024 1.0000 0.1018 0.1052
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 15089 638 0.9090 1.0016 0.0423 0.0383
A-375 Vemurafenib I-BET 0.000 0.000
uM
 72
hr
 2 14872 1575 0.9751 1.0000 0.1059 0.1030
A-375 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 2 14840 1490 0.9441 1.0000 0.1004 0.0814
A-375 Vemurafenib Belinostat 0.000 0.000
uM
 72
hr
 2 14602 1419 1.0065 1.0000 0.0972 0.0803
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 14559 660 0.7276 0.7489 0.0453 0.0459
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 14373 599 0.7211 0.7489 0.0417 0.0459
A-375 Vemurafenib Belinostat 0.000 0.000
uM
 72
hr
 3 14239 660 1.0368 1.0000 0.0464 0.0803
A-375 Vemurafenib I-BET 0.000 0.000
uM
 72
hr
 3 14167 1492 0.9295 1.0000 0.1053 0.1030
A-375 Vemurafenib (+)-JQ1 0.000 0.000
uM
 72
hr
 3 14150 1426 0.8998 1.0000 0.1008 0.0814
A-375 Vemurafenib Belinostat 0.000 0.000
uM
 72
hr
 1 13881 1351 0.9567 1.0000 0.0973 0.0803
A-375 Vemurafenib I-BET151 0.000 0.000
uM
 72
hr
 3 13787 1514 0.8871 1.0000 0.1098 0.1052
A-375 Vemurafenib Defactinib 0.100 0.000
uM
 72
hr
 1 13441 248 0.6323 0.4565 0.0185 0.0200
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 1 11677 368 0.7113 0.6866 0.0315 0.0312
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 3 11246 370 0.6841 0.6866 0.0329 0.0312
A-375 Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 2 10880 316 0.6645 0.6866 0.0290 0.0312
A-375 Vemurafenib I-BET 0.000 1.000
uM
 72
hr
 1 10559 1087 0.6946 0.6207 0.1029 0.0779
A-375 Vemurafenib Defactinib 0.000 1.000
uM
 72
hr
 2 10229 430 0.4696 0.4342 0.0420 0.0408
COLO 858 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 1 10128 1461 1.0290 1.0000 0.1443 0.1501
COLO 858 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 10083 1500 1.0190 1.0000 0.1488 0.1501
A-375 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 9957 502 0.4950 0.4801 0.0504 0.0412
A-375 Vemurafenib PF562271 0.000 1.000
uM
 72
hr
 2 9759 545 0.5012 0.4696 0.0558 0.0532
COLO 858 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 3 9755 1627 0.9650 0.8985 0.1668 0.1651