Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 2 3900 189 0.1943 0.1915 0.0485 0.0418
A-375 Vemurafenib Saracatinib 1.000 0.316
uM
 72
hr
 2 2557 190 0.1239 0.1190 0.0743 0.0733
A-375 Vemurafenib Saracatinib 1.000 0.316
uM
 72
hr
 3 2475 183 0.1200 0.1190 0.0739 0.0733
A-375 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 2 1536 170 0.0715 0.0717 0.1107 0.0989
A-375 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 3 1386 125 0.0660 0.0717 0.0902 0.0989
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 20360 1046 1.0111 1.0000 0.0514 0.0527
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 20251 1109 1.0021 1.0000 0.0548 0.0527
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 16059 813 0.7981 0.7489 0.0506 0.0459
A-375 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 14559 660 0.7276 0.7489 0.0453 0.0459
A-375 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 9020 322 0.4553 0.4801 0.0357 0.0412
A-375 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 3 9724 364 0.4900 0.4801 0.0374 0.0412
A-375 Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 2 6541 255 0.3291 0.3648 0.0390 0.0413
A-375 Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 3 6145 245 0.3089 0.3648 0.0399 0.0413
A-375 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 1 5747 125 0.2943 0.3050 0.0218 0.0212
A-375 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 2 6343 121 0.3257 0.3050 0.0191 0.0212
A-375 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 1 4016 78 0.2061 0.2010 0.0194 0.0218
A-375 Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 2 4327 93 0.2216 0.2010 0.0215 0.0218
A-375 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 2 3199 50 0.1648 0.1687 0.0156 0.0176
A-375 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 3 2686 53 0.1378 0.1687 0.0197 0.0176
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 2 4759 106 0.2436 0.2452 0.0223 0.0214
A-375 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 3 4787 110 0.2448 0.2452 0.0230 0.0214
A-375 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 2 2270 89 0.1142 0.1035 0.0392 0.0423
A-375 Vemurafenib Saracatinib 0.316 1.000
uM
 72
hr
 3 1827 89 0.0910 0.1035 0.0487 0.0423
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 2 3197 255 0.1540 0.1538 0.0798 0.0753
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 1 3381 232 0.1648 0.1538 0.0686 0.0753