Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Saracatinib 0.100 1.000
uM
 72
hr
 1 1024 31 0.7923 0.6896 0.0303 0.0319
MMAC-SF Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 3 1078 44 0.7919 0.7554 0.0408 0.0454
WM-115 Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 2 3246 205 0.7908 0.7665 0.0632 0.0659
MMAC-SF Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 2 854 49 0.7905 0.7915 0.0574 0.0491
WM-115 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 3266 231 0.7892 0.7584 0.0707 0.0699
WM-115 Vemurafenib (+)-JQ1 0.316 0.000
uM
 72
hr
 2 2781 210 0.7888 0.7819 0.0755 0.0740
MZ7-mel Vemurafenib Saracatinib 0.100 0.316
uM
 72
hr
 2 2523 106 0.7883 0.7091 0.0420 0.0504
MZ7-mel Vemurafenib JNK-IN-8 0.000 1.000
uM
 72
hr
 3 2580 113 0.7822 0.8880 0.0438 0.0519
MZ7-mel Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 1 2852 143 0.7815 0.9528 0.0501 0.0436
WM-115 Vemurafenib PF562271 0.100 0.316
uM
 72
hr
 3 3116 226 0.7812 0.7324 0.0725 0.0776
MMAC-SF Vemurafenib PF562271 0.000 1.000
uM
 72
hr
 1 811 41 0.7796 0.6166 0.0506 0.0527
MZ7-mel Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 3 3728 187 0.7781 0.7316 0.0502 0.0510
MMAC-SF Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 2 1139 164 0.7779 0.7237 0.1440 0.1418
WM-115 Vemurafenib I-BET151 0.316 0.000
uM
 72
hr
 2 2905 193 0.7773 0.7662 0.0664 0.0650
MZ7-mel Vemurafenib Defactinib 0.100 0.316
uM
 72
hr
 2 3707 187 0.7735 0.7316 0.0504 0.0510
WM-115 Vemurafenib I-BET 0.316 0.000
uM
 72
hr
 2 2870 175 0.7731 0.7817 0.0610 0.0634
A-375 Vemurafenib Defactinib 0.000 0.316
uM
 72
hr
 1 16963 834 0.7730 0.8197 0.0492 0.0506
MMAC-SF Vemurafenib PF562271 0.000 3.160
uM
 72
hr
 1 792 31 0.7705 0.6021 0.0391 0.0426
WM-115 Vemurafenib JNK-IN-8 0.100 0.000
uM
 72
hr
 2 3291 245 0.7704 0.8272 0.0744 0.0678
WM-115 Vemurafenib I-BET 0.316 0.000
uM
 72
hr
 1 2875 195 0.7688 0.7817 0.0678 0.0634
MZ7-mel Vemurafenib JNK-IN-8 0.100 1.000
uM
 72
hr
 1 2574 151 0.7682 0.5584 0.0587 0.0586
COLO 858 Vemurafenib I-BET 0.000 1.000
uM
 72
hr
 1 2930 418 0.7680 0.7140 0.1427 0.1213
MMAC-SF Vemurafenib JNK-IN-8 0.316 3.160
uM
 72
hr
 1 860 78 0.7679 0.6000 0.0907 0.1021
WM-115 Vemurafenib I-BET151 0.316 0.000
uM
 72
hr
 1 2860 182 0.7676 0.7662 0.0636 0.0650
MZ7-mel Vemurafenib PF562271 0.100 0.000
uM
 72
hr
 3 2777 121 0.7662 0.6853 0.0436 0.0479