Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 1 1253 76 0.9015 1.0853 0.0607 0.0619
MMAC-SF Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 3 1676 108 1.2009 1.0853 0.0644 0.0619
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 3 17737 603 1.0777 1.0016 0.0340 0.0383
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 16836 650 1.0181 1.0016 0.0386 0.0383
A-375 Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 15089 638 0.9090 1.0016 0.0423 0.0383
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 7914 1171 0.9632 1.0000 0.1480 0.1514
COLO 858 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 6958 942 1.0191 1.0000 0.1354 0.1369
WM-115 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 2 4259 258 1.0120 1.0000 0.0606 0.0576
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 18973 930 0.9815 1.0000 0.0490 0.0485
COLO 858 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 6352 878 0.9273 1.0000 0.1382 0.1369
WM-115 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 4035 250 0.9448 1.0000 0.0620 0.0644
WM-115 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 3 3976 233 0.9467 1.0000 0.0586 0.0576
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 19884 1032 0.9869 1.0000 0.0519 0.0527
COLO 858 Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 3 6377 898 0.9086 1.0000 0.1408 0.1426
COLO 858 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 6029 760 0.9502 1.0000 0.1261 0.1418
WM-115 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 1 4014 239 1.0205 1.0000 0.0595 0.0560
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 20251 1109 1.0021 1.0000 0.0548 0.0527
WM-115 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 3766 177 0.9702 1.0000 0.0470 0.0560
WM-115 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 3 3978 244 1.0094 1.0000 0.0613 0.0560
WM-115 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 3889 201 0.9590 1.0000 0.0517 0.0586
A-375 Vemurafenib Defactinib 0.000 0.000
uM
 72
hr
 2 21096 999 0.9631 1.0000 0.0474 0.0468
A-375 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 3 21481 1121 1.0310 1.0000 0.0522 0.0504
A-375 Vemurafenib PF562271 0.000 0.000
uM
 72
hr
 2 19375 946 1.0025 1.0000 0.0488 0.0485
COLO 858 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 8526 1292 1.0334 1.0000 0.1515 0.1514
A-375 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 20360 1046 1.0111 1.0000 0.0514 0.0527