Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MMAC-SF | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 2 | 538 | 203 | 0.3392 | 0.3743 | 0.3773 | 0.3533 |
| MZ7-mel | Vemurafenib | Defactinib | 1.000 | 0.000 | uM | 72 | hr | 1 | 1993 | 318 | 0.3681 | 0.3928 | 0.1596 | 0.1549 |
| MZ7-mel | Vemurafenib | Defactinib | 1.000 | 0.000 | uM | 72 | hr | 2 | 2165 | 324 | 0.4045 | 0.3928 | 0.1497 | 0.1549 |
| MZ7-mel | Vemurafenib | Defactinib | 1.000 | 0.000 | uM | 72 | hr | 3 | 2187 | 340 | 0.4058 | 0.3928 | 0.1555 | 0.1549 |
| A-375 | Vemurafenib | Defactinib | 1.000 | 0.000 | uM | 72 | hr | 3 | 3676 | 151 | 0.1689 | 0.1741 | 0.0411 | 0.0433 |
| A-375 | Vemurafenib | Defactinib | 1.000 | 0.000 | uM | 72 | hr | 2 | 3938 | 167 | 0.1807 | 0.1741 | 0.0424 | 0.0433 |
| WM-115 | Vemurafenib | I-BET | 0.316 | 0.000 | uM | 72 | hr | 1 | 2875 | 195 | 0.7688 | 0.7817 | 0.0678 | 0.0634 |
| MMAC-SF | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 1 | 537 | 167 | 0.3746 | 0.3743 | 0.3110 | 0.3533 |
| MMAC-SF | Vemurafenib | PF562271 | 1.000 | 0.000 | uM | 72 | hr | 3 | 865 | 273 | 0.5994 | 0.5184 | 0.3156 | 0.2893 |
| MMAC-SF | Vemurafenib | PF562271 | 1.000 | 0.000 | uM | 72 | hr | 2 | 711 | 196 | 0.5214 | 0.5184 | 0.2757 | 0.2893 |