Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
A-375 Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 3 6145 245 0.3089 0.3648 0.0399 0.0413
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 1115 1046 0.0099 0.0097 0.9381 0.9430
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 1231 1160 0.0101 0.0097 0.9423 0.9430
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 1247 1183 0.0091 0.0097 0.9487 0.9430
A-375 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 2 1114 238 0.0459 0.0453 0.2136 0.2134
COLO 858 Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 3 2351 292 0.2941 0.3076 0.1242 0.1502
COLO 858 Vemurafenib Defactinib 0.316 3.160
uM
 72
hr
 1 1059 843 0.0256 0.0309 0.7960 0.7785
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 1 921 884 0.0044 0.0047 0.9598 0.9535
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 1 5745 285 0.3434 0.2974 0.0496 0.0491
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 2 1554 62 0.0781 0.0757 0.0399 0.0403
A-375 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 1 3954 69 0.2034 0.1687 0.0175 0.0176
A-375 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 2 3199 50 0.1648 0.1687 0.0156 0.0176
A-375 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 3 2686 53 0.1378 0.1687 0.0197 0.0176
A-375 Vemurafenib JNK-IN-8 0.000 3.160
uM
 72
hr
 3 3476 189 0.2068 0.2974 0.0544 0.0491
COLO 858 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 1128 750 0.0640 0.0618 0.6649 0.6473
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 3 1316 53 0.0661 0.0757 0.0403 0.0403
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 2 1666 709 0.1136 0.1023 0.4256 0.4297
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 1 1609 714 0.1063 0.1023 0.4438 0.4297
COLO 858 Vemurafenib Defactinib 0.000 3.160
uM
 72
hr
 3 1265 531 0.0871 0.1023 0.4198 0.4297
COLO 858 Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 2 1025 921 0.0176 0.0171 0.8985 0.8905
A-375 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 1 1388 90 0.0657 0.0636 0.0648 0.0545
COLO 858 Vemurafenib Defactinib 0.100 3.160
uM
 72
hr
 2 1411 883 0.0627 0.0598 0.6258 0.6178
A-375 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 1649 67 0.0828 0.0757 0.0406 0.0403
MMAC-SF Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 2 572 111 0.4668 0.4489 0.1941 0.1849
MMAC-SF Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 1 642 104 0.5447 0.4489 0.1620 0.1849