Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 2 991 139 0.1872 0.1689 0.1403 0.1617
MZ7-mel Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 3 645 111 0.1173 0.1689 0.1721 0.1617
MZ7-mel Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 2 1571 537 0.3278 0.3216 0.3418 0.3331
MZ7-mel Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 3 1912 646 0.4014 0.3216 0.3379 0.3331
A-375 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 1 2098 334 0.0923 0.0842 0.1592 0.1524
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 3 1093 1032 0.0087 0.0084 0.9442 0.9531
A-375 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 1 3381 232 0.1648 0.1538 0.0686 0.0753
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 1 1135 1078 0.0081 0.0064 0.9498 0.9579
COLO 858 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 3 1681 1503 0.0254 0.0314 0.8941 0.8595
WM-115 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 2072 591 0.3540 0.3601 0.2852 0.2576
COLO 858 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 2 1560 1386 0.0249 0.0314 0.8885 0.8595
COLO 858 Vemurafenib Dasatinib 3.160 0.000
uM
 72
hr
 1 1509 1201 0.0440 0.0314 0.7959 0.8595
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 2 1275 1218 0.0081 0.0084 0.9553 0.9531
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 2 937 901 0.0051 0.0064 0.9616 0.9579
WM-115 Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 3 1606 522 0.2591 0.2721 0.3250 0.3045
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 1 921 884 0.0044 0.0047 0.9598 0.9535
COLO 858 Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 1 1083 877 0.0342 0.0290 0.8098 0.8526
COLO 858 Vemurafenib Dasatinib 3.160 1.000
uM
 72
hr
 1 1440 1382 0.0083 0.0084 0.9597 0.9531
COLO 858 Vemurafenib Dasatinib 3.160 0.316
uM
 72
hr
 3 1090 1049 0.0059 0.0064 0.9624 0.9579
COLO 858 Vemurafenib JNK-IN-8 3.160 0.000
uM
 72
hr
 2 1051 926 0.0207 0.0290 0.8811 0.8526
COLO 858 Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 1 1553 1428 0.0207 0.0156 0.9195 0.9257
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 1 1247 1183 0.0091 0.0097 0.9487 0.9430
COLO 858 Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 3 954 881 0.0121 0.0156 0.9235 0.9257
MZ7-mel Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 2 446 136 0.0983 0.1027 0.3049 0.2808
MZ7-mel Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 1 526 138 0.1230 0.1027 0.2624 0.2808