Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
WM-115 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 2 2322 246 0.5398 0.5553 0.1059 0.0985
WM-115 Vemurafenib Saracatinib 0.100 3.160
uM
 72
hr
 3 2278 211 0.5375 0.5553 0.0926 0.0985
WM-115 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 2 2971 248 0.7081 0.7069 0.0835 0.0799
WM-115 Vemurafenib Saracatinib 0.316 0.000
uM
 72
hr
 3 2855 245 0.6787 0.7069 0.0858 0.0799
WM-115 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 1 4458 280 1.0429 1.0000 0.0628 0.0644
WM-115 Vemurafenib Dasatinib 0.000 0.000
uM
 72
hr
 2 4353 298 1.0122 1.0000 0.0685 0.0644
WM-115 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 1 2653 520 0.5325 0.5321 0.1960 0.1853
WM-115 Vemurafenib Dasatinib 0.000 0.316
uM
 72
hr
 2 2538 469 0.5165 0.5321 0.1848 0.1853
WM-115 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 2 2484 484 0.4993 0.5260 0.1948 0.1795
WM-115 Vemurafenib Dasatinib 0.000 1.000
uM
 72
hr
 3 2626 435 0.5469 0.5260 0.1657 0.1795
WM-115 Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 2 2185 353 0.4573 0.4479 0.1616 0.1688
WM-115 Vemurafenib Dasatinib 0.000 3.160
uM
 72
hr
 3 2059 336 0.4301 0.4479 0.1632 0.1688
WM-115 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 1 2034 549 0.3707 0.3578 0.2699 0.2762
WM-115 Vemurafenib Dasatinib 0.100 0.316
uM
 72
hr
 2 1955 588 0.3412 0.3578 0.3008 0.2762
WM-115 Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 1 1983 575 0.3515 0.3661 0.2900 0.2461
WM-115 Vemurafenib Dasatinib 0.100 1.000
uM
 72
hr
 2 1963 519 0.3605 0.3661 0.2644 0.2461
WM-115 Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 2 1667 411 0.3135 0.3432 0.2466 0.2379
WM-115 Vemurafenib Dasatinib 0.100 3.160
uM
 72
hr
 3 1841 377 0.3655 0.3432 0.2048 0.2379
WM-115 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 2 3197 306 0.7217 0.7092 0.0957 0.0818
WM-115 Vemurafenib Dasatinib 0.316 0.000
uM
 72
hr
 3 3086 246 0.7089 0.7092 0.0797 0.0818
WM-115 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 2 1738 607 0.2823 0.2911 0.3493 0.3460
WM-115 Vemurafenib Dasatinib 0.316 1.000
uM
 72
hr
 3 1717 570 0.2863 0.2911 0.3320 0.3460
WM-115 Vemurafenib Dasatinib 0.316 3.160
uM
 72
hr
 2 1692 540 0.2876 0.2889 0.3191 0.3083
WM-115 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 2 2061 274 0.4647 0.4743 0.1329 0.1338
WM-115 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 1 2173 305 0.4857 0.4743 0.1404 0.1338