Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 2 1142 1078 0.0108 0.0099 0.9440 0.9514
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 1 661 623 0.0064 0.0054 0.9425 0.9547
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 2 1231 1160 0.0101 0.0097 0.9423 0.9430
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 3 688 647 0.0074 0.0092 0.9404 0.9423
COLO 858 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 3 1041 978 0.0104 0.0089 0.9395 0.9423
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 1 595 559 0.0065 0.0058 0.9395 0.9416
COLO 858 Vemurafenib Dasatinib 3.160 3.160
uM
 72
hr
 3 1115 1046 0.0099 0.0097 0.9381 0.9430
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 2 561 526 0.0063 0.0058 0.9376 0.9416
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 1 486 455 0.0056 0.0041 0.9362 0.9488
COLO 858 Vemurafenib JNK-IN-8 3.160 3.160
uM
 72
hr
 1 955 894 0.0101 0.0089 0.9361 0.9423
COLO 858 Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 3 850 795 0.0065 0.0047 0.9353 0.9535
COLO 858 Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 2 1272 1188 0.0139 0.0156 0.9340 0.9257
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 2 832 777 0.0099 0.0092 0.9339 0.9423
COLO 858 Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 3 833 776 0.0103 0.0125 0.9316 0.9029
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 3 1258 1166 0.0131 0.0153 0.9269 0.8976
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 2 736 681 0.0093 0.0093 0.9253 0.9244
COLO 858 Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 3 954 881 0.0121 0.0156 0.9235 0.9257
COLO 858 Vemurafenib JNK-IN-8 3.160 1.000
uM
 72
hr
 1 1553 1428 0.0207 0.0156 0.9195 0.9257
COLO 858 Vemurafenib JNK-IN-8 3.160 0.316
uM
 72
hr
 3 958 874 0.0139 0.0166 0.9123 0.8947
COLO 858 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 3 1810 1651 0.0189 0.0193 0.9122 0.9069
COLO 858 Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 1712 1553 0.0189 0.0193 0.9071 0.9069
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 3 471 427 0.0079 0.0109 0.9066 0.8930
COLO 858 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 1 1107 1003 0.0176 0.0199 0.9061 0.8770
COLO 858 Vemurafenib JNK-IN-8 3.160 0.316
uM
 72
hr
 2 911 825 0.0143 0.0166 0.9056 0.8947
COLO 858 Vemurafenib Dasatinib 1.000 0.316
uM
 72
hr
 2 1187 1073 0.0163 0.0153 0.9040 0.8976