Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | I-BET | 0.000 | 0.000 | uM | 72 | hr | 1 | 3628 | 187 | 0.9871 | 1.0000 | 0.0515 | 0.0556 |
| WM-115 | Vemurafenib | I-BET | 0.000 | 0.000 | uM | 72 | hr | 2 | 3715 | 220 | 1.0026 | 1.0000 | 0.0592 | 0.0556 |
| WM-115 | Vemurafenib | I-BET | 0.000 | 0.000 | uM | 72 | hr | 3 | 3731 | 209 | 1.0103 | 1.0000 | 0.0560 | 0.0556 |
| WM-115 | Vemurafenib | I-BET | 0.000 | 1.000 | uM | 72 | hr | 1 | 3171 | 179 | 0.8583 | 0.8332 | 0.0564 | 0.0539 |
| WM-115 | Vemurafenib | I-BET | 0.000 | 1.000 | uM | 72 | hr | 2 | 2961 | 158 | 0.8041 | 0.8332 | 0.0534 | 0.0539 |
| WM-115 | Vemurafenib | I-BET | 0.000 | 1.000 | uM | 72 | hr | 3 | 3079 | 160 | 0.8373 | 0.8332 | 0.0520 | 0.0539 |
| WM-115 | Vemurafenib | I-BET | 0.100 | 0.000 | uM | 72 | hr | 1 | 3099 | 153 | 0.8451 | 0.9015 | 0.0494 | 0.0495 |
| WM-115 | Vemurafenib | I-BET | 0.100 | 0.000 | uM | 72 | hr | 2 | 3375 | 186 | 0.9148 | 0.9015 | 0.0551 | 0.0495 |
| WM-115 | Vemurafenib | I-BET | 0.100 | 0.000 | uM | 72 | hr | 3 | 3445 | 152 | 0.9446 | 0.9015 | 0.0441 | 0.0495 |
| WM-115 | Vemurafenib | I-BET | 0.100 | 1.000 | uM | 72 | hr | 1 | 2910 | 346 | 0.7355 | 0.6887 | 0.1189 | 0.1170 |
| WM-115 | Vemurafenib | I-BET | 0.100 | 1.000 | uM | 72 | hr | 2 | 2716 | 315 | 0.6888 | 0.6887 | 0.1160 | 0.1170 |
| WM-115 | Vemurafenib | I-BET | 0.100 | 1.000 | uM | 72 | hr | 3 | 2531 | 294 | 0.6417 | 0.6887 | 0.1162 | 0.1170 |
| WM-115 | Vemurafenib | I-BET | 0.316 | 0.000 | uM | 72 | hr | 1 | 2875 | 195 | 0.7688 | 0.7817 | 0.0678 | 0.0634 |
| WM-115 | Vemurafenib | I-BET | 0.316 | 0.000 | uM | 72 | hr | 2 | 2870 | 175 | 0.7731 | 0.7817 | 0.0610 | 0.0634 |
| WM-115 | Vemurafenib | I-BET | 0.316 | 0.000 | uM | 72 | hr | 3 | 2983 | 183 | 0.8032 | 0.7817 | 0.0613 | 0.0634 |
| WM-115 | Vemurafenib | I-BET | 0.316 | 1.000 | uM | 72 | hr | 1 | 2210 | 656 | 0.4458 | 0.4228 | 0.2968 | 0.2821 |
| WM-115 | Vemurafenib | I-BET | 0.316 | 1.000 | uM | 72 | hr | 2 | 2083 | 606 | 0.4237 | 0.4228 | 0.2909 | 0.2821 |
| WM-115 | Vemurafenib | I-BET | 0.316 | 1.000 | uM | 72 | hr | 3 | 1876 | 485 | 0.3990 | 0.4228 | 0.2585 | 0.2821 |
| WM-115 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 1 | 2472 | 246 | 0.6386 | 0.6171 | 0.0995 | 0.1008 |
| WM-115 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 2 | 2390 | 244 | 0.6156 | 0.6171 | 0.1021 | 0.1008 |
| WM-115 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 3 | 2315 | 233 | 0.5972 | 0.6171 | 0.1006 | 0.1008 |
| WM-115 | Vemurafenib | I-BET | 1.000 | 1.000 | uM | 72 | hr | 1 | 1942 | 764 | 0.3379 | 0.3008 | 0.3934 | 0.4036 |
| WM-115 | Vemurafenib | I-BET | 1.000 | 1.000 | uM | 72 | hr | 2 | 1714 | 670 | 0.2995 | 0.3008 | 0.3909 | 0.4036 |
| WM-115 | Vemurafenib | I-BET | 1.000 | 1.000 | uM | 72 | hr | 3 | 1611 | 687 | 0.2651 | 0.3008 | 0.4264 | 0.4036 |
| WM-115 | Vemurafenib | I-BET | 3.160 | 0.000 | uM | 72 | hr | 1 | 2043 | 314 | 0.4960 | 0.4809 | 0.1537 | 0.1624 |