Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
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COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 1.000 | uM | 72 | hr | 3 | 1095 | 559 | 0.1627 | 0.1822 | 0.5105 | 0.4375 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.100 | 0.000 | uM | 72 | hr | 1 | 2066 | 224 | 0.5591 | 0.6614 | 0.1084 | 0.0980 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.100 | 0.000 | uM | 72 | hr | 2 | 2567 | 249 | 0.7036 | 0.6614 | 0.0970 | 0.0980 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.100 | 0.000 | uM | 72 | hr | 3 | 2608 | 231 | 0.7215 | 0.6614 | 0.0886 | 0.0980 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.100 | 1.000 | uM | 72 | hr | 1 | 1296 | 492 | 0.2441 | 0.2165 | 0.3796 | 0.3868 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.100 | 1.000 | uM | 72 | hr | 2 | 1199 | 452 | 0.2268 | 0.2165 | 0.3770 | 0.3868 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.100 | 1.000 | uM | 72 | hr | 3 | 988 | 399 | 0.1788 | 0.2165 | 0.4038 | 0.3868 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.316 | 0.000 | uM | 72 | hr | 1 | 1209 | 207 | 0.3042 | 0.3967 | 0.1712 | 0.1575 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.316 | 0.000 | uM | 72 | hr | 2 | 1604 | 240 | 0.4140 | 0.3967 | 0.1496 | 0.1575 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.316 | 0.000 | uM | 72 | hr | 3 | 1833 | 278 | 0.4720 | 0.3967 | 0.1517 | 0.1575 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.316 | 1.000 | uM | 72 | hr | 1 | 1326 | 956 | 0.1123 | 0.0899 | 0.7210 | 0.7359 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.316 | 1.000 | uM | 72 | hr | 2 | 1110 | 848 | 0.0795 | 0.0899 | 0.7640 | 0.7359 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.316 | 1.000 | uM | 72 | hr | 3 | 923 | 667 | 0.0777 | 0.0899 | 0.7226 | 0.7359 |
COLO 858 | Vemurafenib | (+)-JQ1 | 1.000 | 0.000 | uM | 72 | hr | 1 | 856 | 414 | 0.1342 | 0.2031 | 0.4836 | 0.4582 |
COLO 858 | Vemurafenib | (+)-JQ1 | 1.000 | 0.000 | uM | 72 | hr | 2 | 1215 | 551 | 0.2016 | 0.2031 | 0.4535 | 0.4582 |
COLO 858 | Vemurafenib | (+)-JQ1 | 1.000 | 0.000 | uM | 72 | hr | 3 | 1602 | 701 | 0.2735 | 0.2031 | 0.4376 | 0.4582 |
COLO 858 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 1 | 1542 | 1339 | 0.0616 | 0.0535 | 0.8684 | 0.8621 |
COLO 858 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 2 | 1300 | 1091 | 0.0634 | 0.0535 | 0.8392 | 0.8621 |
COLO 858 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 3 | 964 | 847 | 0.0355 | 0.0535 | 0.8786 | 0.8621 |
COLO 858 | Vemurafenib | (+)-JQ1 | 3.160 | 0.000 | uM | 72 | hr | 1 | 972 | 720 | 0.0765 | 0.0787 | 0.7407 | 0.7868 |
COLO 858 | Vemurafenib | (+)-JQ1 | 3.160 | 0.000 | uM | 72 | hr | 2 | 1300 | 1033 | 0.0810 | 0.0787 | 0.7946 | 0.7868 |
COLO 858 | Vemurafenib | (+)-JQ1 | 3.160 | 0.000 | uM | 72 | hr | 3 | 1480 | 1221 | 0.0786 | 0.0787 | 0.8250 | 0.7868 |
COLO 858 | Vemurafenib | (+)-JQ1 | 3.160 | 1.000 | uM | 72 | hr | 1 | 1645 | 1369 | 0.0838 | 0.0609 | 0.8322 | 0.8549 |
COLO 858 | Vemurafenib | (+)-JQ1 | 3.160 | 1.000 | uM | 72 | hr | 2 | 1419 | 1238 | 0.0549 | 0.0609 | 0.8724 | 0.8549 |
COLO 858 | Vemurafenib | (+)-JQ1 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1037 | 892 | 0.0440 | 0.0609 | 0.8602 | 0.8549 |