Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | (+)-JQ1 | 0.100 | 1.000 | uM | 72 | hr | 2 | 1817 | 782 | 0.3175 | 0.3130 | 0.4304 | 0.4335 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.100 | 1.000 | uM | 72 | hr | 3 | 1722 | 787 | 0.2869 | 0.3130 | 0.4570 | 0.4335 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.316 | 0.000 | uM | 72 | hr | 1 | 2680 | 212 | 0.7572 | 0.7819 | 0.0791 | 0.0740 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.316 | 0.000 | uM | 72 | hr | 2 | 2781 | 210 | 0.7888 | 0.7819 | 0.0755 | 0.0740 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.316 | 0.000 | uM | 72 | hr | 3 | 2794 | 188 | 0.7996 | 0.7819 | 0.0673 | 0.0740 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.316 | 1.000 | uM | 72 | hr | 1 | 1537 | 774 | 0.2341 | 0.2196 | 0.5036 | 0.5363 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.316 | 1.000 | uM | 72 | hr | 2 | 1638 | 901 | 0.2261 | 0.2196 | 0.5501 | 0.5363 |
| WM-115 | Vemurafenib | (+)-JQ1 | 0.316 | 1.000 | uM | 72 | hr | 3 | 1455 | 808 | 0.1985 | 0.2196 | 0.5553 | 0.5363 |
| WM-115 | Vemurafenib | (+)-JQ1 | 1.000 | 0.000 | uM | 72 | hr | 1 | 2192 | 249 | 0.5961 | 0.6325 | 0.1136 | 0.1096 |
| WM-115 | Vemurafenib | (+)-JQ1 | 1.000 | 0.000 | uM | 72 | hr | 2 | 2361 | 275 | 0.6400 | 0.6325 | 0.1165 | 0.1096 |
| WM-115 | Vemurafenib | (+)-JQ1 | 1.000 | 0.000 | uM | 72 | hr | 3 | 2392 | 236 | 0.6615 | 0.6325 | 0.0987 | 0.1096 |
| WM-115 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 1 | 1379 | 759 | 0.1902 | 0.1743 | 0.5504 | 0.5669 |
| WM-115 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 2 | 1376 | 799 | 0.1770 | 0.1743 | 0.5807 | 0.5669 |
| WM-115 | Vemurafenib | (+)-JQ1 | 1.000 | 1.000 | uM | 72 | hr | 3 | 1178 | 671 | 0.1556 | 0.1743 | 0.5696 | 0.5669 |
| WM-115 | Vemurafenib | (+)-JQ1 | 3.160 | 0.000 | uM | 72 | hr | 1 | 1999 | 413 | 0.4866 | 0.4990 | 0.2066 | 0.1975 |
| WM-115 | Vemurafenib | (+)-JQ1 | 3.160 | 0.000 | uM | 72 | hr | 2 | 2188 | 416 | 0.5437 | 0.4990 | 0.1901 | 0.1975 |
| WM-115 | Vemurafenib | (+)-JQ1 | 3.160 | 0.000 | uM | 72 | hr | 3 | 1891 | 370 | 0.4667 | 0.4990 | 0.1957 | 0.1975 |
| WM-115 | Vemurafenib | (+)-JQ1 | 3.160 | 1.000 | uM | 72 | hr | 1 | 1305 | 739 | 0.1737 | 0.1677 | 0.5663 | 0.5580 |
| WM-115 | Vemurafenib | (+)-JQ1 | 3.160 | 1.000 | uM | 72 | hr | 2 | 1263 | 699 | 0.1730 | 0.1677 | 0.5534 | 0.5580 |
| WM-115 | Vemurafenib | (+)-JQ1 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1144 | 634 | 0.1565 | 0.1677 | 0.5542 | 0.5580 |
| WM-115 | Vemurafenib | Belinostat | 0.000 | 0.000 | uM | 72 | hr | 1 | 3852 | 180 | 1.0529 | 1.0000 | 0.0467 | 0.0525 |
| WM-115 | Vemurafenib | Belinostat | 0.000 | 0.000 | uM | 72 | hr | 2 | 3627 | 193 | 0.9846 | 1.0000 | 0.0532 | 0.0525 |
| WM-115 | Vemurafenib | Belinostat | 0.000 | 0.000 | uM | 72 | hr | 3 | 3562 | 205 | 0.9625 | 1.0000 | 0.0576 | 0.0525 |
| WM-115 | Vemurafenib | Belinostat | 0.000 | 1.000 | uM | 72 | hr | 1 | 2039 | 101 | 0.5557 | 0.4993 | 0.0495 | 0.0637 |
| WM-115 | Vemurafenib | Belinostat | 0.000 | 1.000 | uM | 72 | hr | 2 | 1806 | 127 | 0.4814 | 0.4993 | 0.0703 | 0.0637 |