Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MZ7-mel Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 2 1667 202 0.3219 0.3139 0.1212 0.1064
MZ7-mel Vemurafenib Defactinib 1.000 0.316
uM
 72
hr
 3 1711 175 0.3375 0.3139 0.1023 0.1064
MZ7-mel Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 1 2034 207 0.4015 0.3194 0.1018 0.1150
MZ7-mel Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 2 1821 211 0.3538 0.3194 0.1159 0.1150
MZ7-mel Vemurafenib Defactinib 1.000 1.000
uM
 72
hr
 3 1059 135 0.2030 0.3194 0.1275 0.1150
MZ7-mel Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 1 1614 181 0.3149 0.2476 0.1121 0.1178
MZ7-mel Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 2 1341 132 0.2657 0.2476 0.0984 0.1178
MZ7-mel Vemurafenib Defactinib 1.000 3.160
uM
 72
hr
 3 862 123 0.1624 0.2476 0.1427 0.1178
MZ7-mel Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 1 1852 508 0.2953 0.2848 0.2743 0.3145
MZ7-mel Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 2 1837 600 0.2718 0.2848 0.3266 0.3145
MZ7-mel Vemurafenib Defactinib 3.160 0.000
uM
 72
hr
 3 1988 681 0.2872 0.2848 0.3426 0.3145
MZ7-mel Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 1 837 184 0.1435 0.1699 0.2198 0.2362
MZ7-mel Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 2 1140 287 0.1874 0.1699 0.2518 0.2362
MZ7-mel Vemurafenib Defactinib 3.160 0.316
uM
 72
hr
 3 1067 253 0.1789 0.1699 0.2371 0.2362
MZ7-mel Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 1 1812 386 0.3133 0.2468 0.2130 0.2247
MZ7-mel Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 2 1653 376 0.2806 0.2468 0.2275 0.2247
MZ7-mel Vemurafenib Defactinib 3.160 1.000
uM
 72
hr
 3 869 203 0.1463 0.2468 0.2336 0.2247
MZ7-mel Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 1 1112 192 0.2022 0.1689 0.1727 0.1617
MZ7-mel Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 2 991 139 0.1872 0.1689 0.1403 0.1617
MZ7-mel Vemurafenib Defactinib 3.160 3.160
uM
 72
hr
 3 645 111 0.1173 0.1689 0.1721 0.1617
MZ7-mel Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 1 3229 262 0.9407 1.0000 0.0811 0.0720
MZ7-mel Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 2 3322 249 0.9743 1.0000 0.0750 0.0720
MZ7-mel Vemurafenib JNK-IN-8 0.000 0.000
uM
 72
hr
 3 3640 218 1.0850 1.0000 0.0599 0.0720
MZ7-mel Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 1 3616 276 1.0590 1.5833 0.0763 0.0617
MZ7-mel Vemurafenib JNK-IN-8 0.000 0.316
uM
 72
hr
 2 5203 279 1.5612 1.5833 0.0536 0.0617