Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
MMAC-SF Vemurafenib PF562271 0.100 1.000
uM
 72
hr
 3 502 35 0.4728 0.5724 0.0697 0.0768
MMAC-SF Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 1 642 104 0.5447 0.4489 0.1620 0.1849
MMAC-SF Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 2 572 111 0.4668 0.4489 0.1941 0.1849
MMAC-SF Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 3 413 82 0.3351 0.4489 0.1985 0.1849
MMAC-SF Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 1 642 98 0.5508 0.6679 0.1526 0.1517
MMAC-SF Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 2 832 118 0.7229 0.6679 0.1418 0.1517
MMAC-SF Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 3 859 138 0.7300 0.6679 0.1607 0.1517
MMAC-SF Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 1 609 115 0.5002 0.5785 0.1888 0.1867
MMAC-SF Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 2 652 130 0.5285 0.5785 0.1994 0.1867
MMAC-SF Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 3 843 145 0.7067 0.5785 0.1720 0.1867
MMAC-SF Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 1 655 120 0.5417 0.4404 0.1832 0.1902
MMAC-SF Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 2 591 123 0.4738 0.4404 0.2081 0.1902
MMAC-SF Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 3 368 66 0.3058 0.4404 0.1793 0.1902
MMAC-SF Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 1 413 133 0.2835 0.2531 0.3220 0.3208
MMAC-SF Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 2 367 115 0.2551 0.2531 0.3134 0.3208
MMAC-SF Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 3 324 106 0.2207 0.2531 0.3272 0.3208
MMAC-SF Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 1 593 164 0.4344 0.5184 0.2766 0.2893
MMAC-SF Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 2 711 196 0.5214 0.5184 0.2757 0.2893
MMAC-SF Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 3 865 273 0.5994 0.5184 0.3156 0.2893
MMAC-SF Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 1 493 140 0.3574 0.3881 0.2840 0.2937
MMAC-SF Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 2 557 171 0.3908 0.3881 0.3070 0.2937
MMAC-SF Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 3 579 168 0.4161 0.3881 0.2902 0.2937
MMAC-SF Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 1 590 212 0.3827 0.3044 0.3593 0.3533
MMAC-SF Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 2 472 162 0.3139 0.3044 0.3432 0.3533
MMAC-SF Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 3 333 119 0.2167 0.3044 0.3574 0.3533