Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | JNK-IN-8 | 3.160 | 1.000 | uM | 72 | hr | 2 | 1793 | 524 | 0.3210 | 0.3012 | 0.2922 | 0.3083 |
| WM-115 | Vemurafenib | JNK-IN-8 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1567 | 472 | 0.2770 | 0.3012 | 0.3012 | 0.3083 |
| WM-115 | Vemurafenib | JNK-IN-8 | 3.160 | 3.160 | uM | 72 | hr | 1 | 1455 | 735 | 0.1821 | 0.1449 | 0.5052 | 0.5769 |
| WM-115 | Vemurafenib | JNK-IN-8 | 3.160 | 3.160 | uM | 72 | hr | 2 | 1315 | 786 | 0.1338 | 0.1449 | 0.5977 | 0.5769 |
| WM-115 | Vemurafenib | JNK-IN-8 | 3.160 | 3.160 | uM | 72 | hr | 3 | 1263 | 793 | 0.1189 | 0.1449 | 0.6279 | 0.5769 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 0.000 | uM | 72 | hr | 1 | 4014 | 239 | 1.0205 | 1.0000 | 0.0595 | 0.0560 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 0.000 | uM | 72 | hr | 2 | 3766 | 177 | 0.9702 | 1.0000 | 0.0470 | 0.0560 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 0.000 | uM | 72 | hr | 3 | 3978 | 244 | 1.0094 | 1.0000 | 0.0613 | 0.0560 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 0.316 | uM | 72 | hr | 1 | 3445 | 252 | 0.8631 | 0.8917 | 0.0731 | 0.0781 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 0.316 | uM | 72 | hr | 2 | 3626 | 294 | 0.9007 | 0.8917 | 0.0811 | 0.0781 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 0.316 | uM | 72 | hr | 3 | 3665 | 294 | 0.9112 | 0.8917 | 0.0802 | 0.0781 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 1.000 | uM | 72 | hr | 1 | 2632 | 217 | 0.6528 | 0.6373 | 0.0824 | 0.0814 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 1.000 | uM | 72 | hr | 2 | 2619 | 241 | 0.6428 | 0.6373 | 0.0920 | 0.0814 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 1.000 | uM | 72 | hr | 3 | 2451 | 171 | 0.6163 | 0.6373 | 0.0698 | 0.0814 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 3.160 | uM | 72 | hr | 1 | 1782 | 284 | 0.4049 | 0.3987 | 0.1594 | 0.1587 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 3.160 | uM | 72 | hr | 2 | 1820 | 339 | 0.4003 | 0.3987 | 0.1863 | 0.1587 |
| WM-115 | Vemurafenib | PF562271 | 0.000 | 3.160 | uM | 72 | hr | 3 | 1663 | 217 | 0.3909 | 0.3987 | 0.1305 | 0.1587 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 0.000 | uM | 72 | hr | 1 | 3379 | 210 | 0.8566 | 0.8829 | 0.0621 | 0.0676 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 0.000 | uM | 72 | hr | 2 | 3554 | 228 | 0.8991 | 0.8829 | 0.0642 | 0.0676 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 0.000 | uM | 72 | hr | 3 | 3577 | 274 | 0.8929 | 0.8829 | 0.0766 | 0.0676 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 0.316 | uM | 72 | hr | 1 | 2653 | 212 | 0.6598 | 0.7324 | 0.0799 | 0.0776 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 0.316 | uM | 72 | hr | 2 | 3041 | 244 | 0.7561 | 0.7324 | 0.0802 | 0.0776 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 0.316 | uM | 72 | hr | 3 | 3116 | 226 | 0.7812 | 0.7324 | 0.0725 | 0.0776 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 1.000 | uM | 72 | hr | 1 | 2441 | 228 | 0.5982 | 0.6104 | 0.0934 | 0.0822 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 1.000 | uM | 72 | hr | 2 | 2521 | 205 | 0.6261 | 0.6104 | 0.0813 | 0.0822 |