Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib Saracatinib 0.316 3.160
uM
 72
hr
 3 1051 677 0.0634 0.0618 0.6441 0.6473
COLO 858 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 1 1420 605 0.1381 0.1369 0.4261 0.4519
COLO 858 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 2 1359 632 0.1232 0.1369 0.4650 0.4519
COLO 858 Vemurafenib Saracatinib 1.000 0.000
uM
 72
hr
 3 1647 765 0.1494 0.1369 0.4645 0.4519
COLO 858 Vemurafenib Saracatinib 1.000 0.316
uM
 72
hr
 1 703 475 0.0386 0.0355 0.6757 0.7189
COLO 858 Vemurafenib Saracatinib 1.000 0.316
uM
 72
hr
 2 622 430 0.0325 0.0355 0.6913 0.7189
COLO 858 Vemurafenib Saracatinib 1.000 0.316
uM
 72
hr
 3 989 781 0.0352 0.0355 0.7897 0.7189
COLO 858 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 1 1107 1003 0.0176 0.0199 0.9061 0.8770
COLO 858 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 2 1013 887 0.0213 0.0199 0.8756 0.8770
COLO 858 Vemurafenib Saracatinib 1.000 1.000
uM
 72
hr
 3 810 688 0.0207 0.0199 0.8494 0.8770
COLO 858 Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 1 917 823 0.0159 0.0171 0.8975 0.8905
COLO 858 Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 2 1025 921 0.0176 0.0171 0.8985 0.8905
COLO 858 Vemurafenib Saracatinib 1.000 3.160
uM
 72
hr
 3 835 731 0.0176 0.0171 0.8754 0.8905
COLO 858 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 1 1155 902 0.0429 0.0307 0.7810 0.8523
COLO 858 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 2 1110 992 0.0200 0.0307 0.8937 0.8523
COLO 858 Vemurafenib Saracatinib 3.160 0.000
uM
 72
hr
 3 1459 1287 0.0291 0.0307 0.8821 0.8523
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 1 694 626 0.0115 0.0093 0.9020 0.9244
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 2 736 681 0.0093 0.0093 0.9253 0.9244
COLO 858 Vemurafenib Saracatinib 3.160 0.316
uM
 72
hr
 3 759 718 0.0069 0.0093 0.9460 0.9244
COLO 858 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 1 1539 1471 0.0115 0.0099 0.9558 0.9514
COLO 858 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 2 1142 1078 0.0108 0.0099 0.9440 0.9514
COLO 858 Vemurafenib Saracatinib 3.160 1.000
uM
 72
hr
 3 963 919 0.0075 0.0099 0.9543 0.9514
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 1 661 623 0.0064 0.0054 0.9425 0.9547
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 2 726 696 0.0051 0.0054 0.9587 0.9547
COLO 858 Vemurafenib Saracatinib 3.160 3.160
uM
 72
hr
 3 752 724 0.0047 0.0054 0.9628 0.9547