Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 7877.001 | uM | 0.29497 | 4.43060 | -0.4638 | -1.0000 | 0.4055 | 0.4308 | 0.9496 | 0.4366 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9469.001 | uM | 0.52608 | 2.84380 | -0.9770 | -1.0000 | 0.6511 | 0.4475 | 0.9108 | 1.0202 | |
| MDA-MB-175-VII | HR+ | Luminal | ZM-447439 | AURK | AURK | 10642.138 | uM | 19.16960 | 29.1850 | -0.9994 | -1.0000 | 2.6137 | 0.4105 | 0.7449 | 0.5620 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7909.001 | uM | 0.02771 | 0.03019 | -0.5424 | -0.1327 | 2.7489 | 0.5962 | 0.8630 | 1.5909 | |
| MDA-MB-468 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7907.001 | uM | 0.01541 | 0.01787 | -0.7783 | -0.5487 | 5.0000 | 0.8713 | 0.9517 | 1.3308 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 12365.169 | uM | inf | 0.64004 | 0.6059 | 0.6378 | 3.4420 | 0.1185 | 0.9695 | 2.1831 | |
| HCC1954 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 11055.15 | uM | inf | 9.430 | 0.6980 | 0.6805 | 2.2535 | 0.0021 | 0.8973 | 1.6412 | |
| MDA-MB-415 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10938.15 | uM | inf | inf | 0.5380 | 0.5380 | 0.0000 | 0.3086 | -0.0630 | 1.0480 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 11937.16 | uM | inf | 1.19910 | 0.4066 | 0.6165 | 0.9085 | 0.1548 | 0.6398 | 2.4144 | |
| MB 157 | Unknown | Unknown | ZM-447439 | AURK | AURK | 12580.169 | uM | 0.75556 | 0.81963 | -0.3346 | -0.2512 | 5.0000 | 0.3762 | 0.9926 | 2.1524 | |
| SUM149PT | TNBC | Basal B | ZM-447439 | AURK | AURK | 10819.15 | uM | inf | 27.26040 | 0.8794 | 0.7689 | 0.3455 | 0.0375 | 0.8282 | 2.1256 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7813.001 | uM | 5.56960 | 8.06020 | -0.9735 | -1.0000 | 2.9723 | 0.1992 | 0.9944 | 0.7338 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10577.138 | uM | inf | inf | 0.6876 | 0.6876 | 0.0000 | 0.0865 | 0.3763 | 1.0408 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 12400.169 | uM | 1.11250 | 1.22350 | -0.3407 | -0.1309 | 2.4440 | 0.4028 | 0.9234 | 1.2449 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 7816.001 | uM | 0.59860 | 2.77790 | -0.9806 | -1.0000 | 0.7158 | 0.4383 | 0.9545 | 1.0243 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9254.001 | uM | 5.38610 | 6.70950 | -1.0000 | -0.9998 | 5.0000 | 0.3079 | 0.9082 | 0.3986 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10937.15 | uM | 72.81410 | 997.6140 | 0.5754 | -0.5774 | 0.2933 | 0.1313 | 0.9014 | 1.3769 | |
| MCF12A | NM | Basal B | ZM-447439 | AURK | AURK | 10817.15 | uM | 1.17690 | 0.58024 | 0.4320 | 0.4359 | 2.9038 | 0.1795 | 0.9924 | 1.3689 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 9347.001 | uM | 1.42620 | 8.85950 | -0.5083 | -1.0000 | 0.6015 | 0.3327 | 0.9368 | 1.5003 | |
| SUM149PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 9830.001 | uM | 6.16220 | 13.3660 | -0.4504 | -0.8863 | 1.3171 | 0.1630 | 0.9960 | 2.0346 | |
| MCF 10A | NM | Basal B | GSK1070916 | AURK | AURK | 9551.001 | uM | 1.7540 | 36.29570 | -0.0203 | -1.0000 | 0.3626 | 0.2778 | 0.9514 | 2.6913 | |
| HCC1569 | HER2amp | Basal A | GSK1070916 | AURK | AURK | 7825.001 | uM | 0.64893 | 4.17490 | -0.7698 | -1.0000 | 0.5902 | 0.4203 | 0.9327 | 1.5991 | |
| Hs 578T | TNBC | Basal B | GSK1070916 | AURK | AURK | 9511.001 | uM | 0.40958 | 2.1680 | -0.9784 | -1.0000 | 0.6593 | 0.4700 | 0.9579 | 1.1698 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7896.001 | uM | 7.70880 | 10.54470 | -0.9698 | -1.0000 | 3.5070 | 0.1637 | 0.9943 | 1.1912 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9258.001 | uM | 0.09421 | 1.1910 | -0.9841 | -1.0000 | 0.4330 | 0.6113 | 0.8765 | 0.7137 |