Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | Nilotinib | ABL | nRTK | 11855.145 | uM | inf | inf | 0.3444 | 0.3444 | 0.0000 | 0.3027 | 0.5178 | 0.5070 | |
| 600MPE | HR+ | Luminal | Nilotinib | ABL | nRTK | 12224.145 | uM | inf | inf | 0.9894 | 0.9894 | 0.0000 | -0.0249 | -0.6099 | 0.9737 | |
| MCF7 | HR+ | Luminal | Nilotinib | ABL | nRTK | 10997.145 | uM | inf | inf | 1.0396 | 1.0396 | 0.0000 | 0.0666 | 0.0029 | 1.3945 | |
| MDA-MB-134-VI | HR+ | Luminal | Nilotinib | ABL | nRTK | 10998.145 | uM | inf | inf | 0.8805 | 0.8805 | 0.0000 | 0.1761 | 0.0000 | 0.9403 | |
| MDA-MB-157 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12594.17 | uM | inf | inf | 0.8144 | 0.8144 | 0.0000 | 0.0415 | 0.5417 | 1.2180 | |
| HCC1395 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12000.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0614 | 0.0000 | 0.6084 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12178.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0369 | 0.0948 | 0.6127 | |
| HCC1428 | HR+ | Luminal | Nilotinib | ABL | nRTK | 11936.145 | uM | inf | 2.17830 | 0.5045 | 0.5364 | 5.0000 | 0.1750 | 0.8994 | 0.8451 | |
| HCC1569 | HER2amp | Basal A | Nilotinib | ABL | nRTK | 10872.145 | uM | inf | inf | 1.0423 | 1.0423 | 0.0000 | 0.0067 | 0.0000 | 1.6308 | |
| BT-20 | TNBC | Basal A | Nilotinib | ABL | nRTK | 10581.145 | uM | 16.74520 | 10.16160 | 0.3643 | 0.3665 | 2.6440 | 0.1747 | 0.9485 | 0.9044 | |
| BT-20 | TNBC | Basal A | Nilotinib | ABL | nRTK | 11854.145 | uM | inf | 7.90530 | 0.4616 | 0.5489 | 5.0000 | 0.1255 | 0.8664 | 1.1581 | |
| AU565 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 10880.145 | uM | inf | inf | 0.9804 | 0.9804 | 0.0000 | 0.0621 | 0.0247 | 1.4751 | |
| BT-549 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12305.17 | uM | inf | 1.80680 | 0.8403 | 0.8115 | 4.9996 | 0.0758 | 0.8551 | 2.7728 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12056.145 | uM | inf | inf | 0.9538 | 0.9538 | 0.0000 | 0.0958 | 0.3538 | 0.8365 | |
| CAMA-1 | HR+ | Luminal | Nilotinib | ABL | nRTK | 12070.145 | uM | inf | inf | 0.8990 | 0.8990 | 0.0000 | 0.1345 | 0.0301 | 1.0737 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12291.17 | uM | inf | inf | 0.6458 | 0.6458 | 0.0000 | 0.2392 | 0.3142 | 0.5585 | |
| 184B5 | NM | Basal | Nilotinib | ABL | nRTK | 12566.17 | uM | inf | 0.08710 | 0.9223 | 0.9254 | 0.8046 | 0.0464 | 0.8541 | 1.4648 | |
| HCC1143 | TNBC | Basal A | Nilotinib | ABL | nRTK | 12112.145 | uM | inf | inf | 0.9353 | 0.9353 | 0.0000 | 0.0338 | 0.0179 | 1.9247 | |
| HCC38 | TNBC | Basal B | Nilotinib | ABL | nRTK | 11850.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0017 | -0.0001 | 2.1492 | |
| HCC1187 | TNBC | Basal A | Nilotinib | ABL | nRTK | 10753.145 | uM | 410.88640 | 1000.00000 | 0.5140 | -0.1122 | 0.2277 | 0.1893 | 0.7339 | 1.5180 | |
| HCC70 | TNBC | Basal A | Nilotinib | ABL | nRTK | 12400.17 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0014 | -0.0040 | 1.1992 | |
| BT-483 | HR+ | Luminal | Nilotinib | ABL | nRTK | 10696.145 | uM | inf | inf | 0.6817 | 0.6817 | 0.0000 | 0.2546 | 0.0751 | 0.3316 | |
| HCC1395 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12084.145 | uM | inf | 2.91120 | 0.7469 | 0.7472 | 5.0000 | 0.0902 | 0.9079 | 1.1692 | |
| MDA-MB-361 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 10999.145 | uM | inf | inf | 0.7649 | 0.7649 | 0.0000 | 0.0831 | 0.3014 | 0.7621 | |
| MDA-MB-361 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12379.17 | uM | inf | inf | 0.9413 | 0.9413 | 0.0000 | -0.0239 | -0.0238 | 0.5805 |