Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 11849.158 | uM | 11.40840 | 18.59730 | -0.9207 | -1.0000 | 2.2482 | 0.2623 | 0.9849 | 1.4054 | |
| HCC3153 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10577.141 | uM | 8.0270 | 56.07330 | -0.0634 | -1.0000 | 0.5652 | 0.2508 | 0.9124 | 0.9203 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12178.158 | uM | 1.57950 | 4.28540 | -0.8896 | -1.0000 | 1.1007 | 0.4947 | 0.9798 | 0.7379 | |
| HCC1419 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12001.165 | uM | 0.81605 | 3.11870 | -0.9607 | -1.0000 | 0.8194 | 0.5612 | 0.9606 | 0.5382 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10518.141 | uM | 4.60660 | 11.04240 | -0.9668 | -1.0000 | 1.2566 | 0.3372 | 0.9742 | 1.3122 | |
| HCC1937 | TNBC | Basal A | Triciribine | AKT | AKT | 7452.074 | uM | 11.71590 | 3.05490 | 0.4011 | 0.3068 | 0.7075 | 0.1258 | 0.9737 | 1.5162 | |
| HCC3153 | TNBC | Basal A | Triciribine | AKT | AKT | 7467.074 | uM | 0.24441 | 1.67330 | -0.2225 | -0.5644 | 0.3927 | 0.4313 | 0.9791 | 1.2457 | |
| MDA-MB-134-VI | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12206.158 | uM | 11.50920 | 17.9770 | -0.9531 | -1.0000 | 2.4636 | 0.2873 | 0.9735 | 1.1431 | |
| MDA-MB-157 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12594.165 | uM | 14.42930 | 18.00520 | -0.9472 | -0.9508 | 4.8113 | 0.1719 | 0.9959 | 1.4798 | |
| 184A1 | NM | Basal | Sigma A6730 | AKT | AKT | 12509.165 | uM | 3.14240 | 13.05610 | -0.6553 | -1.0000 | 0.7714 | 0.3161 | 0.9885 | 1.5022 | |
| CAMA-1 | HR+ | Luminal | Triciribine | AKT | AKT | 5911.074 | uM | 0.71750 | 77.1850 | 0.0662 | -1.0000 | 0.2348 | 0.3781 | 0.9378 | 1.1317 | |
| BT-483 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10696.153 | uM | 1.1750 | 2.84060 | -0.6524 | -0.6846 | 0.9772 | 0.4348 | 0.9803 | 0.5484 | |
| HCC1143 | TNBC | Basal A | Triciribine | AKT | AKT | 7430.074 | uM | 3.52560 | 68.90220 | 0.1321 | -0.9991 | 0.3694 | 0.2363 | 0.9801 | 1.6943 | |
| HCC1187 | TNBC | Basal A | Sigma A6730 | AKT | AKT | 10753.153 | uM | 3.79880 | 10.50580 | -0.9537 | -1.0000 | 1.0800 | 0.3248 | 0.9712 | 1.3879 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 7492.074 | uM | 0.27441 | 0.34225 | -0.0961 | -0.1118 | 0.9138 | 0.4035 | 0.9951 | 1.4222 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12291.165 | uM | 0.08918 | 0.66991 | -0.9980 | -1.0000 | 0.5448 | 0.8274 | 0.8520 | 0.5602 | |
| 184A1 | NM | Basal | Triciribine | AKT | AKT | 5895.074 | uM | 0.08792 | 0.23992 | -0.7686 | -0.7129 | 0.8827 | 0.6419 | 0.9956 | 1.1218 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 7493.074 | uM | 0.12436 | 0.26451 | -0.3977 | -0.4199 | 0.8079 | 0.5445 | 0.9983 | 1.1549 | |
| BT-20 | TNBC | Basal A | Triciribine | AKT | AKT | 5903.074 | uM | 1.02210 | 3.13290 | -0.3635 | -0.6039 | 0.7071 | 0.3330 | 0.9862 | 1.0729 | |
| BT-474 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12056.158 | uM | 0.72952 | 3.1890 | -0.8607 | -1.0000 | 0.7448 | 0.5557 | 0.9726 | 0.9929 | |
| HCC1187 | TNBC | Basal A | Triciribine | AKT | AKT | 7432.074 | uM | 0.09985 | 0.94087 | -0.7596 | -1.0000 | 0.4898 | 0.5937 | 0.9931 | 0.8598 | |
| MCF7 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10997.153 | uM | 1.66070 | 4.34240 | -0.9658 | -1.0000 | 1.1430 | 0.4990 | 0.9842 | 1.0771 | |
| MCF12A | NM | Basal B | Triciribine | AKT | AKT | 7490.074 | uM | 0.14525 | 0.62186 | -0.2052 | -0.4305 | 0.4271 | 0.4807 | 0.9960 | 2.6912 | |
| HCC1569 | HER2amp | Basal A | Sigma A6730 | AKT | AKT | 10872.153 | uM | 9.73860 | 17.79130 | -0.8670 | -1.0000 | 1.8231 | 0.2406 | 0.9913 | 1.5576 | |
| HCC2185 | TNBC | Luminal | Sigma A6730 | AKT | AKT | 12192.158 | uM | 2.37830 | 7.77320 | -0.7569 | -1.0000 | 0.9276 | 0.3892 | 0.9796 | 0.6680 |