Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 10694.152 | uM | 1.76060 | 2.19680 | -0.7631 | -0.7576 | 4.1672 | 0.5809 | 0.9994 | 2.4238 | |
| 184B5 | NM | Basal | NSC 663284 | CDC25 | CDC | 12566.152 | uM | 2.37290 | 3.20490 | -0.8860 | -0.8796 | 3.3767 | 0.5784 | 0.9988 | 1.4827 | |
| CAMA-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12070.159 | uM | 2.01710 | 2.54470 | -0.9763 | -0.9749 | 4.6561 | 0.6449 | 0.9948 | 0.9846 | |
| CAMA-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10473.14 | uM | 2.43380 | 4.24210 | -0.9447 | -0.9624 | 1.9316 | 0.5953 | 0.9964 | 1.3126 | |
| HCC1187 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 10753.152 | uM | 1.64750 | 2.07090 | -0.9245 | -0.9236 | 4.5754 | 0.6920 | 0.9905 | 1.3690 | |
| SUM149PT | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 10819.152 | uM | 2.21710 | 3.43830 | -0.8698 | -0.8529 | 2.2686 | 0.5471 | 0.9988 | 2.0116 | |
| BT-549 | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 12305.152 | uM | 1.60690 | 2.04520 | -0.8290 | -0.7672 | 3.8550 | 0.6192 | 0.9945 | 2.9694 | |
| SUM1315MO2 | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 12428.152 | uM | 1.13290 | 1.65830 | -0.9802 | -0.9909 | 2.8676 | 0.7650 | 0.9912 | 0.8719 | |
| MDA-MB-134-VI | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10998.152 | uM | 6.51530 | 9.26380 | -0.9923 | -1.0000 | 3.1214 | 0.5036 | 0.9857 | 0.8517 | |
| CAMA-1 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10755.152 | uM | 1.8650 | 2.76950 | -0.9988 | -1.0000 | 2.7783 | 0.7200 | 0.9787 | 0.5859 | |
| SUM149PT | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 11937.159 | uM | 1.99530 | 2.88610 | -0.8038 | -0.7919 | 2.5716 | 0.5538 | 0.9994 | 2.2200 | |
| SK-BR-3 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 11851.159 | uM | 1.39190 | 2.24970 | -0.9542 | -0.9582 | 2.2292 | 0.6704 | 0.9966 | 1.2582 | |
| HCC1569 | HER2amp | Basal A | NSC 663284 | CDC25 | CDC | 12523.152 | uM | 5.08010 | 6.32050 | -0.9908 | -0.9907 | 5.0000 | 0.4820 | 0.9979 | 0.8423 | |
| 600MPE | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12224.152 | uM | 3.0690 | 3.80580 | -0.9666 | -0.9662 | 5.0000 | 0.6239 | 0.9973 | 1.0761 | |
| MX1 | Unknown | Unknown | NSC 663284 | CDC25 | CDC | 10644.14 | uM | 0.66207 | 0.82476 | -1.0000 | -1.0000 | 5.0000 | 0.8690 | 0.9955 | 0.4302 | |
| MX1 | Unknown | Unknown | NSC 663284 | CDC25 | CDC | 12220.159 | uM | 0.150 | 0.25801 | -0.9998 | -1.0000 | 2.0255 | 1.0392 | 0.9923 | 0.4788 | |
| MX1 | Unknown | Unknown | NSC 663284 | CDC25 | CDC | 10874.152 | uM | 0.62316 | 0.99765 | -0.9943 | -1.0000 | 2.3345 | 0.7910 | 0.9986 | 0.7706 | |
| HCC1569 | HER2amp | Basal A | NSC 663284 | CDC25 | CDC | 10872.152 | uM | 2.81980 | 4.65580 | -0.9020 | -0.9178 | 2.0785 | 0.5801 | 0.9909 | 1.5916 | |
| BT-483 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 11855.159 | uM | 1.26610 | 3.4830 | -0.9988 | -1.0000 | 1.0857 | 0.6157 | 0.9930 | 0.6347 | |
| MDA-MB-453 | TNBC | Luminal | NSC 663284 | CDC25 | CDC | 12414.152 | uM | 4.71940 | 6.00170 | -0.9511 | -0.9503 | 4.4304 | 0.5576 | 0.9910 | 1.1325 | |
| HCC70 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 10873.152 | uM | 2.85030 | 5.92010 | -0.9625 | -1.0000 | 1.5031 | 0.5523 | 0.9855 | 1.1577 | |
| HCC70 | TNBC | Basal A | NSC 663284 | CDC25 | CDC | 12400.152 | uM | 3.32670 | 5.80610 | -0.9357 | -0.9641 | 1.9291 | 0.5522 | 0.9942 | 1.1392 | |
| MDA-MB-415 | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 12333.152 | uM | 1.79460 | 2.59180 | -0.9877 | -0.9899 | 2.9705 | 0.6897 | 0.9806 | 0.7371 | |
| 184A1 | NM | Basal | NSC 663284 | CDC25 | CDC | 12509.152 | uM | 1.61730 | 2.02890 | -0.9303 | -0.9290 | 4.6320 | 0.6528 | 0.9971 | 1.3755 | |
| MDA-MB-361 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 10643.14 | uM | 4.11240 | 5.87110 | -1.0000 | -1.0000 | 3.0857 | 0.5047 | 0.9986 | 0.5078 |