Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9453.001 | uM | 0.18090 | 1.87020 | -0.9029 | -1.0000 | 0.4703 | 0.5168 | 0.9195 | 1.2616 | |
| HCC3153 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10937.15 | uM | 15.75670 | 29.68360 | -0.1024 | -1.0000 | 1.7347 | 0.1284 | 0.9444 | 1.3769 | |
| HCC1143 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7810.001 | uM | 1.93580 | 6.36580 | -0.8483 | -1.0000 | 0.9229 | 0.3410 | 0.9271 | 0.9063 | |
| HCC1569 | HER2amp | Basal A | ZM-447439 | AURK | AURK | 10872.15 | uM | inf | 0.35621 | 0.5700 | 0.5657 | 1.8837 | 0.1901 | 0.8828 | 1.6255 | |
| HCC38 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11850.16 | uM | 0.16510 | 0.47277 | -0.5340 | -0.4837 | 0.6432 | 0.4725 | 0.9405 | 1.8797 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 7808.001 | uM | 0.19841 | 1.24310 | -0.9041 | -1.0000 | 0.5987 | 0.5723 | 0.9550 | 2.5321 | |
| HBL-100 | Unknown | Unknown | GSK1070916 | AURK | AURK | 9226.001 | uM | 0.70349 | 3.20790 | -0.7877 | -1.0000 | 0.7241 | 0.4535 | 0.9635 | 2.6569 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10577.138 | uM | inf | inf | 0.6876 | 0.6876 | 0.0000 | 0.0865 | 0.3763 | 1.0408 | |
| HCC3153 | TNBC | Basal A | ZM-447439 | AURK | AURK | 10937.15 | uM | 72.81410 | 997.6140 | 0.5754 | -0.5774 | 0.2933 | 0.1313 | 0.9014 | 1.3769 | |
| HCC38 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10578.138 | uM | 0.45998 | 5.02680 | -0.7596 | -1.0000 | 0.4594 | 0.5328 | 0.9576 | 1.7866 | |
| HCC3153 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10577.138 | uM | 21.55120 | 25.77270 | -0.7204 | -0.7223 | 4.9971 | 0.1693 | 0.9917 | 1.0408 | |
| HCC1187 | TNBC | Basal A | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10518.138 | uM | 0.09728 | 0.11455 | -0.5380 | -0.2289 | 2.3063 | 0.6356 | 0.9308 | 1.3413 | |
| HCC1419 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 12001.169 | uM | 3.57110 | 22.85030 | -0.2400 | -1.0000 | 0.5919 | 0.2981 | 0.9468 | 0.7194 | |
| HCC38 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9469.001 | uM | 0.52608 | 2.84380 | -0.9770 | -1.0000 | 0.6511 | 0.4475 | 0.9108 | 1.0202 | |
| HCC70 | TNBC | Basal A | ZM-447439 | AURK | AURK | 12400.169 | uM | 1.11250 | 1.22350 | -0.3407 | -0.1309 | 2.4440 | 0.4028 | 0.9234 | 1.2449 | |
| MCF7 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10997.15 | uM | inf | inf | 0.7198 | 0.7198 | 0.0000 | 0.1640 | 0.5121 | 1.4218 | |
| CAMA-1 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10473.138 | uM | 46.97660 | 66.64340 | -0.5527 | -0.9899 | 3.1221 | 0.1387 | 0.9705 | 1.2872 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 10056.001 | uM | 12.78590 | 52.63390 | 0.1678 | -1.0000 | 0.7764 | 0.1357 | 0.9744 | 0.9052 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9278.001 | uM | 6.59160 | 6.92790 | -0.1408 | -0.1412 | 5.0000 | 0.1504 | 0.9445 | 0.4429 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7820.001 | uM | 7.71170 | 6.43760 | 0.2975 | 0.2973 | 4.9992 | 0.1058 | 0.9438 | 0.7692 | |
| HCC3153 | TNBC | Basal A | GSK1070916 | AURK | AURK | 7853.001 | uM | 8.20720 | 30.58260 | -0.0642 | -1.0000 | 0.8352 | 0.1798 | 0.9652 | 1.5775 | |
| HCC2185 | TNBC | Luminal | ZM-447439 | AURK | AURK | 12192.16 | uM | 1.27190 | 0.63873 | 0.1767 | 0.2379 | 0.9378 | 0.3421 | 0.9088 | 0.7363 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10019.001 | uM | 6.32170 | 7.28910 | -0.5182 | -0.5189 | 4.9999 | 0.2040 | 0.9453 | 0.3968 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 10473.138 | uM | inf | 0.52667 | 0.7059 | 0.7725 | 1.9365 | 0.1088 | 0.7415 | 1.2872 | |
| CAMA-1 | HR+ | Luminal | ZM-447439 | AURK | AURK | 12070.16 | uM | 1.57910 | 13.1750 | -0.8353 | -1.0000 | 0.5179 | 0.4318 | 0.8564 | 0.8453 |