Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7462.085 | uM | 7.59760 | 7.15830 | -0.5274 | 0.0497 | 1.7575 | 0.3660 | 0.6025 | 0.3896 | |
| HCC1419 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10019.002 | uM | 0.47272 | 1.90670 | 0.0482 | -0.3033 | 0.3399 | 0.3675 | 0.7925 | 0.3915 | |
| HCC1419 | HER2amp | Luminal | Docetaxel | TUBB | TUBB | 10019.002 | uM | 0.03102 | 0.02212 | 0.3860 | 0.4078 | 4.9999 | 0.2530 | 0.9570 | 0.3915 | |
| HCC1187 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7811.04 | uM | 1.04690 | 1.38930 | -1.0000 | -0.9258 | 3.7023 | 0.7792 | 0.8482 | 0.3921 | |
| HCC1187 | TNBC | Basal A | Geldanamycin | HSP90 | HSP90 | 7811.04 | uM | 0.05228 | 0.06299 | -0.8492 | -0.7691 | 5.0000 | 0.9963 | 0.9944 | 0.3921 | |
| T47D | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9897.034 | uM | 0.49263 | 0.95061 | -0.7852 | -0.6884 | 1.3170 | 0.5463 | 0.9875 | 0.3940 | |
| T47D | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9897.034 | uM | 0.09833 | 5.57170 | -0.9954 | -1.0000 | 0.2721 | 1.0422 | 0.8289 | 0.3940 | ||
| T47D | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9897.034 | uM | 0.02730 | 0.05890 | -0.9992 | -0.8255 | 1.2678 | 1.0020 | 0.9728 | 0.3940 | |
| HCC2185 | TNBC | Luminal | Vorinostat | HDAC | HDAC | 7462.065 | uM | 37.55690 | 65.95580 | -1.0000 | -1.0000 | 1.9509 | 0.9428 | 0.9838 | 0.3950 | |
| HCC2185 | TNBC | Luminal | Trichostatin A | HDAC | HDAC | 7462.065 | uM | 22.21550 | 27.67390 | -1.0000 | -0.9998 | 5.0000 | 0.8649 | 0.9889 | 0.3950 | |
| HCC2185 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7462.065 | uM | inf | 12.12690 | 0.5787 | 0.6650 | 4.9993 | 0.1530 | 0.7936 | 0.3950 | |
| UACC-812 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10267.001 | uM | 0.01301 | 0.01496 | -0.4705 | -0.5070 | 4.9999 | 0.8669 | 0.9914 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10267.001 | uM | 6.73740 | 8.15430 | -0.7961 | -0.7976 | 4.9966 | 0.2231 | 0.8483 | 0.3957 | |
| UACC-812 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10267.001 | uM | 25.76520 | 31.49210 | -0.0613 | -0.8640 | 5.0000 | 0.0577 | 0.9247 | 0.3957 | |
| HCC1419 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 10019.001 | uM | 6.32170 | 7.28910 | -0.5182 | -0.5189 | 4.9999 | 0.2040 | 0.9453 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10019.001 | uM | 1.07080 | 10.8130 | -0.4023 | -1.0000 | 0.4751 | 0.3243 | 0.8739 | 0.3968 | |
| HCC1419 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10019.001 | uM | 7.27140 | 9.02660 | -0.9678 | -0.9707 | 4.9898 | 0.1937 | 0.9732 | 0.3968 | |
| HCC202 | HER2amp | Luminal | Dichloroacetate | PDK | PDK | 13135.176 | uM | 5.15650 | 270.40390 | 0.4671 | -1.0000 | 0.2775 | 0.1576 | 0.6760 | 0.3972 | |
| HCC1395 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9254.002 | uM | 0.00740 | 0.00860 | -0.5219 | -0.5591 | 5.0000 | 0.8610 | 0.9829 | 0.3983 | |
| HCC1395 | TNBC | Basal B | Taxol | TUBB | TUBB | 9254.002 | uM | 0.02485 | 0.02967 | -0.9237 | -0.7129 | 5.0000 | 0.9198 | 0.9866 | 0.3983 | |
| HCC1395 | TNBC | Basal B | GSK1070916 | AURK | AURK | 9254.001 | uM | 5.38610 | 6.70950 | -1.0000 | -0.9998 | 5.0000 | 0.3079 | 0.9082 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9254.001 | uM | 0.02742 | 0.03281 | -0.9898 | -0.7258 | 5.0000 | 0.9333 | 0.9796 | 0.3986 | |
| HCC1395 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9254.001 | uM | 0.00450 | 0.00522 | -1.0000 | -0.5435 | 5.0000 | 1.0717 | 0.8911 | 0.3986 | |
| MDA-MB-134-VI | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 10077.026 | uM | 7.0350 | 7.93710 | 0.4622 | -0.4084 | 4.9480 | -0.0133 | 0.9348 | 0.3999 | |
| MDA-MB-134-VI | HR+ | Luminal | Cetuximab | EGFR | ErbB | 10077.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.3999 |