Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 5898.095 | uM | 0.05465 | 2.31930 | -0.9967 | -1.0000 | 0.2931 | 0.5721 | 0.6309 | 0.6975 | |
| SUM185PE | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 15332.203 | uM | 0.00634 | 0.00850 | -0.9967 | -0.9967 | 3.7282 | 1.4136 | 0.9927 | 0.7106 | |
| HCC70 | TNBC | Basal A | 5-FU | TYMS | TYMS | 9501.03 | uM | 119.68470 | 224.99790 | -0.9966 | -1.0000 | 1.7404 | 0.7253 | 0.9866 | 0.6902 | |
| MDA-MB-453 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7516.092 | uM | 18.17450 | 22.59320 | -0.9966 | -0.9844 | 5.0000 | 0.5268 | 0.9905 | 1.1035 | |
| MDA-MB-468 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 7905.037 | uM | 0.86819 | 1.05230 | -0.9966 | -0.8080 | 5.0000 | 0.6312 | 0.9702 | 0.6714 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 9708.121 | uM | 0.18334 | 0.25399 | -0.9966 | -0.8676 | 3.0870 | 0.8315 | 0.9948 | 1.1394 | |
| MCF12A | NM | Basal B | Topotecan | TOP1 | TOP | 7491.078 | uM | 0.00884 | 0.07326 | -0.9966 | -1.0000 | 0.5196 | 1.1630 | 0.9783 | 0.7238 | |
| MDA-MB-361 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 10999.144 | uM | 0.10770 | 2.01460 | -0.9966 | -1.0000 | 0.3751 | 0.7048 | 0.9305 | 0.6880 | |
| HCC1419 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 7437.065 | uM | 122.60150 | 227.06390 | -0.9966 | -1.0000 | 1.7826 | 0.7118 | 0.9918 | 0.5183 | |
| SUM1315MO2 | TNBC | Basal B | NSC 663284 | CDC25 | CDC | 10875.152 | uM | 0.93379 | 1.83720 | -0.9966 | -1.0000 | 1.6234 | 0.7461 | 0.9886 | 0.7465 | |
| MDA-MB-175-VII | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 12126.144 | uM | 0.13868 | 10.22450 | -0.9966 | -1.0000 | 0.2555 | 0.5966 | 0.6164 | 0.6379 | |
| MDA-MB-468 | TNBC | Basal A | Taxol | TUBB | TUBB | 7905.002 | uM | 0.00606 | 0.00753 | -0.9966 | -0.9878 | 5.0000 | 1.4358 | 0.8612 | 0.4198 | |
| UACC-812 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 11938.147 | uM | 2.2020 | 5.74120 | -0.9966 | -1.0000 | 1.1465 | 0.5389 | 0.8836 | 0.6765 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 5905.067 | uM | 0.03788 | 0.21488 | -0.9965 | -1.0000 | 0.6329 | 0.7563 | 0.9348 | 0.7991 | |
| BT-474 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 12291.152 | uM | 1.41260 | 2.14060 | -0.9965 | -1.0000 | 2.6431 | 0.7780 | 0.9658 | 0.6792 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9158.001 | uM | inf | inf | -0.9965 | -0.9965 | 0.0000 | 0.3194 | 0.2618 | 0.6988 | |
| MX1 | Unknown | Unknown | Everolimus | MTOR | MTOR | 10874.156 | uM | 0.71673 | 6.36150 | -0.9965 | -1.0000 | 0.5032 | 0.4598 | 0.8230 | 0.6949 | |
| UACC-812 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 10267.131 | uM | 15.31250 | 68.22830 | -0.9965 | -1.0000 | 0.7353 | 0.8841 | 0.9909 | 0.3849 | |
| HCC1428 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7442.085 | uM | 0.00643 | 0.01886 | -0.9964 | -1.0000 | 1.0202 | 1.1658 | 0.9946 | 0.8237 | |
| MDA-MB-453 | TNBC | Luminal | Nelfinavir | 12964.174 | uM | 5.03420 | 8.04630 | -0.9964 | -1.0000 | 2.3427 | 0.2872 | 0.9802 | 0.7885 | |||
| MCF7 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7493.095 | uM | 0.00008 | 0.02291 | -0.9964 | -1.0000 | 0.1944 | 1.0719 | 0.7483 | 1.0092 | |
| MDA-MB-415 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7511.091 | uM | 20.21780 | 30.49470 | -0.9964 | -1.0000 | 2.6731 | 0.5022 | 0.9870 | 1.0995 | |
| BT-474 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 12291.143 | uM | 717.16620 | 1000.00000 | -0.9964 | -0.7984 | 2.8704 | 0.3234 | 0.9803 | 0.5621 | |
| BT-20 | TNBC | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 5903.09 | uM | 14.23390 | 26.11670 | -0.9964 | -1.0000 | 1.8101 | 0.5188 | 0.9862 | 0.9291 | |
| 184A1 | NM | Basal | Vinorelbine | TUBB | TUBB | 7787.018 | uM | inf | inf | -0.9963 | -0.9963 | 0.0000 | 0.4831 | 0.4499 | 0.3791 |