Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM1315MO2 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 9044.074 | uM | 0.03803 | 0.06612 | -0.9994 | -0.9731 | 1.9532 | 1.1764 | 0.9971 | 0.6607 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7508.067 | uM | 9.14220 | 11.38870 | -0.9994 | -1.0000 | 5.0000 | 0.4106 | 0.9941 | 0.7560 | |
| SUM1315MO2 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 9044.074 | uM | 0.03803 | 0.06612 | -0.9994 | -0.9731 | 1.9532 | 1.1764 | 0.9971 | 0.6607 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12178.154 | uM | 0.27381 | 1.07140 | -0.9994 | -1.0000 | 0.8053 | 0.5291 | 0.9912 | 0.5170 | |
| MX1 | Unknown | Unknown | ZM-447439 | AURK | AURK | 10644.138 | uM | 0.42739 | 0.67816 | -0.9994 | -0.7754 | 2.0282 | 0.7559 | 0.9401 | 0.5624 | |
| MDA-MB-157 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 10093.034 | uM | 0.00588 | 0.06554 | -0.9994 | -1.0000 | 0.4558 | 1.1551 | 0.8879 | 0.9732 | |
| MX1 | Unknown | Unknown | Bortezomib | Proteasome | Proteasome | 14918.203 | uM | 0.00872 | 0.01466 | -0.9994 | -0.9980 | 2.1115 | 1.3233 | 0.9984 | 0.5296 | |
| MCF 10F | NM | - | Ixabepilone | TUBB | TUBB | 7486.095 | uM | 0.00829 | 0.10436 | -0.9993 | -1.0000 | 0.4338 | 0.9187 | 0.9127 | 0.9448 | |
| MDA-MB-175-VII | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7500.091 | uM | 14.29550 | 19.80740 | -0.9993 | -0.9996 | 3.3680 | 0.5434 | 0.9889 | 0.6237 | |
| HCC1428 | HR+ | Luminal | Methylglyoxal | 13107.184 | uM | 509.5660 | 1000.00000 | -0.9993 | -0.8247 | 1.4452 | 0.5248 | 0.9454 | 0.6454 | |||
| HCC2185 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 10263.034 | uM | 0.59694 | 64.10150 | -0.9993 | -1.0000 | 0.2349 | 0.7794 | 0.7511 | 0.3750 | ||
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7432.074 | uM | 0.01535 | 0.02166 | -0.9993 | -0.9985 | 3.1914 | 1.3750 | 0.9993 | 0.8598 | |
| HCC1419 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7820.042 | uM | 0.01058 | 0.45734 | -0.9993 | -1.0000 | 0.2917 | 0.7971 | 0.8795 | 0.5216 | |
| BT-474 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5905.067 | uM | 10.87560 | 13.54810 | -0.9993 | -1.0000 | 5.0000 | 0.3691 | 0.9961 | 0.7991 | |
| UACC-812 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 10420.095 | uM | 0.00405 | 0.00426 | -0.9993 | -0.0422 | 1.5655 | 0.6669 | 0.5965 | 0.5783 | |
| SUM225CWN | HER2amp | Basal A | Imatinib | ABL/KIT/PDGFR | nRTK | 7534.091 | uM | 10.57980 | 18.55160 | -0.9993 | -1.0000 | 1.9562 | 0.5265 | 0.9981 | 0.9898 | |
| BT-474 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9163.03 | uM | 26.3970 | 32.88280 | -0.9993 | -0.9998 | 5.0000 | 0.3249 | 0.9959 | 0.3535 | |
| MDA-MB-134-VI | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10265.021 | uM | 248.53190 | 343.89760 | -0.9993 | -1.0000 | 3.3827 | 0.2219 | 0.9702 | 0.3095 | |
| MDA-MB-361 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 12379.167 | uM | 0.02259 | 0.04640 | -0.9993 | -1.0000 | 1.5262 | 1.0200 | 0.9966 | 0.5212 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7444.067 | uM | 0.15890 | 1.56350 | -0.9993 | -1.0000 | 0.4805 | 0.5040 | 0.8779 | 0.7382 | |
| MDA-MB-361 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 12379.152 | uM | 5.22920 | 6.51350 | -0.9993 | -0.9993 | 5.0000 | 0.4739 | 0.9978 | 0.5297 | |
| HCC1187 | TNBC | Basal A | Bortezomib | Proteasome | Proteasome | 7432.074 | uM | 0.01535 | 0.02166 | -0.9993 | -0.9985 | 3.1914 | 1.3750 | 0.9993 | 0.8598 | |
| HCC2185 | TNBC | Luminal | LBH589 | HDAC | HDAC | 10996.154 | uM | 0.05942 | 0.08509 | -0.9993 | -0.9983 | 3.0573 | 0.9216 | 0.9981 | 0.5230 | |
| HCC1419 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9278.037 | uM | 0.02447 | 0.03619 | -0.9993 | -0.9737 | 2.7625 | 1.1989 | 0.9991 | 0.3822 | |
| MDA-MB-175-VII | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7500.067 | uM | 0.11677 | 1.55590 | -0.9993 | -1.0000 | 0.4242 | 0.5568 | 0.7848 | 0.7143 |