Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | Olomoucine II | CDK1 | CDK | 10816.147 | uM | 5.0970 | 6.34790 | -0.9997 | -0.9981 | 5.0000 | 0.4155 | 0.9979 | 0.7283 | |
| SUM225CWN | HER2amp | Basal A | Fascaplysin | CDK4 | CDK | 7534.084 | uM | 0.03012 | 0.08208 | -0.9997 | -1.0000 | 1.0956 | 0.9283 | 0.9950 | 0.8905 | |
| MX1 | Unknown | Unknown | Valproic acid | HDAC | HDAC | 12220.143 | uM | 16.61280 | 137.74590 | -0.9997 | -1.0000 | 0.5194 | 0.8265 | 0.8979 | 0.4532 | |
| HCC1187 | TNBC | Basal A | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9244.021 | uM | 2.44470 | 3.04470 | -0.9997 | -0.9980 | 5.0000 | 0.8270 | 0.9985 | 0.4542 | |
| HCC2185 | TNBC | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7849.011 | uM | 4.30770 | 11.64210 | -0.9997 | -1.0000 | 1.1050 | 0.6329 | 0.9992 | 0.5467 | |
| MDA-MB-415 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12959.177 | uM | 0.04903 | 0.06108 | -0.9997 | -0.9996 | 5.0000 | 0.9551 | 0.9974 | 0.5538 | |
| BT-483 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 5908.067 | uM | 0.06348 | 1.02470 | -0.9997 | -1.0000 | 0.3950 | 0.6678 | 0.6757 | 0.5143 | |
| BT-20 | TNBC | Basal A | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14116.189 | uM | 0.11656 | 0.17087 | -0.9997 | -1.0000 | 2.8722 | 1.1707 | 0.7408 | 0.5416 | |
| MDA-MB-175-VII | HR+ | Luminal | NSC 663284 | CDC25 | CDC | 10642.14 | uM | 4.82050 | 8.19110 | -0.9997 | -1.0000 | 2.0722 | 0.6033 | 0.9324 | 0.5473 | |
| HCC1419 | HER2amp | Luminal | Bortezomib | Proteasome | Proteasome | 7437.074 | uM | 0.03991 | 0.04961 | -0.9997 | -0.9835 | 5.0000 | 1.2451 | 0.9986 | 0.3747 | |
| HCC1187 | TNBC | Basal A | 5-FU | TYMS | TYMS | 7811.017 | uM | 12.20530 | 48.34130 | -0.9997 | -1.0000 | 0.7982 | 1.0316 | 0.9194 | 0.3604 | |
| MDA-MB-361 | HER2amp | Luminal | Methylglyoxal | 13516.184 | uM | 483.18040 | 1000.00000 | -0.9997 | -0.7768 | 1.2889 | 0.4930 | 0.9292 | 0.5643 | |||
| MDA-MB-415 | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 7510.084 | uM | 0.05728 | 0.15305 | -0.9997 | -1.0000 | 1.1178 | 0.8785 | 0.9881 | 0.8702 | |
| MDA-MB-415 | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 7897.007 | uM | 0.35013 | 0.44871 | -0.9997 | -0.6929 | 3.5049 | 0.7207 | 0.9579 | 0.8772 | |
| HCC202 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7458.091 | uM | 8.85040 | 19.21130 | -0.9997 | -1.0000 | 1.4175 | 0.5855 | 0.9822 | 0.5499 | |
| HCC1187 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 9244.034 | uM | 0.04058 | 0.09838 | -0.9997 | -1.0000 | 1.2406 | 1.0601 | 0.9910 | 0.6294 | |
| BT-474 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12291.165 | uM | 0.00084 | 0.00487 | -0.9997 | -1.0000 | 0.6233 | 1.4610 | 0.9623 | 0.5602 | |
| 184A1 | NM | Basal | CGC-11047 | Polyamine analogue | 9047.026 | uM | 5.67110 | 70.62780 | -0.9997 | -1.0000 | 0.4356 | 0.7516 | 0.8174 | 0.5972 | ||
| HCC202 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7844.001 | uM | inf | inf | -0.9997 | -0.9997 | 0.0000 | 0.8273 | 0.4411 | 0.3060 | |
| HCC1395 | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7435.084 | uM | 0.27572 | 0.41327 | -0.9997 | -1.0000 | 2.7144 | 0.7084 | 0.9961 | 0.8646 | |
| HCC1419 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 12001.168 | uM | 0.02662 | 0.04483 | -0.9997 | -0.4264 | 1.1833 | 0.8384 | 0.8693 | 0.4934 | |
| MDA-MB-453 | TNBC | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7518.067 | uM | 5.55180 | 6.91490 | -0.9997 | -0.9988 | 5.0000 | 0.5773 | 0.8581 | 0.7666 | |
| MCF12A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 7491.05 | uM | 0.01557 | 0.03316 | -0.9997 | -1.0000 | 1.4537 | 1.2798 | 0.9830 | 0.5814 | |
| HCC70 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 9501.121 | uM | 0.26936 | 0.55094 | -0.9997 | -1.0000 | 1.5353 | 0.7865 | 0.9962 | 0.7121 | |
| MDA-MB-361 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 10643.147 | uM | 0.76279 | 1.21570 | -0.9997 | -1.0000 | 2.3572 | 0.6131 | 0.9972 | 0.6347 |